Repetitive transcranial magnetic stimulation enhances spatial learning and synaptic plasticity via the VEGF and BDNF–NMDAR pathways in a rat model of vascular dementia

Zhang, N.; Xing, Mengya; Wang, Y.; Huang, Tao; Cheng, Yan

doi:10.1016/j.neuroscience.2015.10.038

Cited by 86 publications

(58 citation statements)

References 41 publications

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“…Stem cell implantation combined with EE and therapies directed at attenuating neuroinflammation produced the highest number of successes and thus these viable promising approaches warrant continued research. Other non-pharmacological therapies that have shown some success when provided singly include electrical and magnetic brain stimulation (Li et al, 2015; Zhang et al, 2015; Clayton et al, 2016), constrained-induced movement therapy (Brady and Garcia, 2009) and low-level laser therapy (Oron et al, 2012; Xuan et al, 2013) and may potentially be more effective when augmented by a secondary therapy. Lastly, it is important that potential therapies be evaluated by several independent groups so that the results are replicated.…”

Section: Discussionmentioning

confidence: 99%

Combination therapies for neurobehavioral and cognitive recovery after experimental traumatic brain injury: Is more better?

Kline

Leary

Radabaugh

et al. 2016

Progress in Neurobiology

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Traumatic brain injury (TBI) is a significant health care crisis that affects two million individuals in the United Sates alone and over ten million worldwide each year. While numerous monotherapies have been evaluated and shown to be beneficial at the bench, similar results have not translated to the clinic. One reason for the lack of successful translation may be due to the fact that TBI is a heterogeneous disease that affects multiple mechanisms, thus requiring a therapeutic approach that can act on complementary, rather than single, targets. Hence, the use of combination therapies (i.e., polytherapy) has emerged as a viable approach. Stringent criteria, such as verification of each individual treatment plus the combination, a focus on behavioral outcome, and post-injury vs. pre-injury treatments, were employed to determine which studies were appropriate for review. The selection process resulted in 37 papers that fit the specifications. The review, which is the first to comprehensively assess the effects of combination therapies on behavioral outcomes after TBI, encompasses five broad categories (inflammation, oxidative stress, neurotransmitter dysregulation, neurotrophins, and stem cells, with and without rehabilitative therapies). Overall, the findings suggest that combination therapies can be more beneficial than monotherapies as indicated by 46% of the studies exhibiting an additive or synergistic positive effect versus on 19% reporting a negative interaction. These encouraging findings serve as an impetus for continued combination studies after TBI and ultimately for the development of successful clinically relevant therapies.

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Section: Discussionmentioning

confidence: 99%

Combination therapies for neurobehavioral and cognitive recovery after experimental traumatic brain injury: Is more better?

Kline

Leary

Radabaugh

et al. 2016

Progress in Neurobiology

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“…Repetitive transcranial magnetic stimulation (rTMS) is a safe and noninvasive form of neural stimulation that applies focal magnetic fields to generate electric currents in the brain (Barker, Freeston, Jalinous, Merton, & Morton, ) and can increase or decrease neuronal firing depending on the intensity, frequency, and pattern of stimulation (Hoppenrath, Hartig, & Funke, ; Müller‐Dahlhaus & Vlachos, ; Tang, Thickbroom, & Rodger, ). rTMS exerts this effect on neuronal activity by modulating the activity of gamma‐aminobutyric acid (GABA)‐ and glutamate‐releasing neurons (Croarkin et al, ; Hoppenrath & Funke, ; Lenz et al, ; Lenz et al, ; Vlachos et al, ), increasing intracellular calcium levels (Grehl et al, ) and promoting the release of growth factors such as brain‐derived neurotrophic factor (BDNF) (Castillo‐Padilla & Funke, ; Makowiecki, Harvey, Sherrard, & Rodger, ; Müller, Toschi, Kresse, Post, & Keck, ; Zhang, Xing, Wang, Tao, & Cheng, )—all of which are key regulators of oligodendrogenesis and adaptive myelination (Gautier et al, ; Hamilton et al, ; Pitman & Young, ; Wong, Xiao, Kemper, Kilpatrick, & Murray, ; Xiao et al, ). For these reasons, rTMS has the potential to influence adaptive myelination, and ultimately find application in the repair of demyelinated lesions in the CNS of people with multiple sclerosis (MS).…”

Section: Introductionmentioning

confidence: 99%

Low‐intensity transcranial magnetic stimulation promotes the survival and maturation of newborn oligodendrocytes in the adult mouse brain

Cullen

Senesi

Tang

et al. 2019

Glia

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Neuronal activity is a potent extrinsic regulator of oligodendrocyte generation and central nervous system myelination. Clinically, repetitive transcranial magnetic stimulation (rTMS) is delivered to noninvasively modulate neuronal activity; however, the ability of rTMS to facilitate adaptive myelination has not been explored. By performing cre‐lox lineage tracing, to follow the fate of oligodendrocyte progenitor cells in the adult mouse brain, we determined that low intensity rTMS (LI‐rTMS), administered as an intermittent theta burst stimulation, but not as a continuous theta burst or 10 Hz stimulation, increased the number of newborn oligodendrocytes in the adult mouse cortex. LI‐rTMS did not alter oligodendrogenesis per se, but instead increased cell survival and enhanced myelination. These data suggest that LI‐rTMS can be used to noninvasively promote myelin addition to the brain, which has potential implications for the treatment of demyelinating diseases such as multiple sclerosis.

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“…rTMS at appropriate frequency, intensity, and duration may alter the expression of neurotrophins and their receptors [12, 23, 29, 30], neurotransmitters and their receptors [14, 30-32], and structural proteins [12, 23] in synapses, which in turn affects the postsynaptic depolarization, inducing LTP or LTD and contributing to different cognitive functions.…”

Section: Discussionmentioning

confidence: 99%

The Role of Hippocampal Structural Synaptic Plasticity in Repetitive Transcranial Magnetic Stimulation to Improve Cognitive Function in Male SAMP8 Mice

Wang

et al. 2017

Cell Physiol Biochem

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Background: Repetitive transcranial magnetic stimulation (rTMS) has been used to improve cognitive function, but the stimulation protocols are variable and the underlying mechanism is unclear. Therefore, we intend to examine whether 5Hz rTMS with 30% maximum output could improve cognitive functions in senescence-accelerated-prone mouse 8 (SAMP8) through changing synaptic plasticity. Methods: SAMP8 and senescence-accelerated-prone mouse/resistant 1 (SAMR1) (7-month old male) were randomly divided into 3 groups: SMAP8 rTMS group (P8-rTMS), SMAP8 sham-rTMS group (P8-sham), and SAMR1 sham-rTMS group (R1-sham). The P8-rTMS group was treated daily with 5Hz rTMS with 30% maximum output for 14 consecutive days, whereas the other two groups were controls without rTMS stimulation. Morris water maze (MWM) experiment was performed after rTMS or sham treatment to assess the effect of rTMS on cognitive function. Reverse transcription polymerase chain reaction and Western blot assays were used to detect the mRNA and protein expression of presynaptic Synapsin (SYN) and postsynaptic density 95 (PSD95) in the hippocampus of these mice. Results: The mean escape latency of the P8-rTMS group was significantly shorter than that of the P8-sham group. The number of platform crossings of the P8-rTMS group was significantly higher than that of the P8-sham group. rTMS significantly upregulated the protein and mRNA expression of SYN and PSD95 in the hippocampus of p8-rTMS mice compared to those of P8 sham mice. Conclusion: 5Hz rTMS with 30% maximum output enhances learning and memory in the SAMP8 mice. This improvement may be associated with the increased expression of synaptic structure proteins SYN and PSD95 in the hippocampus.

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Repetitive transcranial magnetic stimulation enhances spatial learning and synaptic plasticity via the VEGF and BDNF–NMDAR pathways in a rat model of vascular dementia

Cited by 86 publications

References 41 publications

Combination therapies for neurobehavioral and cognitive recovery after experimental traumatic brain injury: Is more better?

Combination therapies for neurobehavioral and cognitive recovery after experimental traumatic brain injury: Is more better?

Low‐intensity transcranial magnetic stimulation promotes the survival and maturation of newborn oligodendrocytes in the adult mouse brain

The Role of Hippocampal Structural Synaptic Plasticity in Repetitive Transcranial Magnetic Stimulation to Improve Cognitive Function in Male SAMP8 Mice

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