Repigmentación del pelo canoso tras tratamiento con hormona tiroidea

Redondo, Pedro; Guzmán, M.; Marquina, M.; Pretel, Maider; Aguado, Leyre; Lloret, Paloma Braza; Gorrochategui, Alazne Aizpitarte

doi:10.1016/s0001-7310(07)70145-x

Cited by 22 publications

(6 citation statements)

References 41 publications

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“…They reported that thyroid hormone exerts influence by stimulating gene expression of keratins 6, 16, and 17 [11, 12, 14]. Redondo et al [25] observed beneficial effects of thyroid hormone on stimulating growth of hair shafts in vitro and enhancing hair growth, proliferation of melanocytes and repigmentation of gray hair in vivo . This improvement may be related to the direct effects of thyroid hormone on thyroid hormone receptors that have been detected in fibroblasts, cells of the papillary dermis, cells of the outer root sheath and hair follicles [10].…”

Section: Discussionmentioning

confidence: 99%

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Aloe vera gel and thyroid hormone cream may improve wound healing in Wistar rats

et al. 2012

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Therapeutic effects of various treatment options in wound healing have been one of the most controversial issues in surgical science. The present study was carried out to examine and compare the effects of Aloe vera gel, thyroid hormone cream and silver sulfadiazine cream onsutured incisions in Wistar rats. In a randomized controlled trial, thirty-six Wistar male rats, 250 to 300 g, received surgical incisions followed by topical application of Aloe vera gel, thyroid hormone cream and silver sulfadiazine 1%. To assess the efficacy of each treatment technique, a histological approach was used to evaluate the mean number of fibroblasts, macrophages, neutrophils, blood vessel sections and thickness of the regenerating epithelium and dermis on days 4, 7 and 14. Re-epithelialization and angiogenesis were significantly improved in Aloe vera gel group compared with the other treatments while thyroid hormone cream had positive effects on day 4 (P≤0.05). Topical administration of Aloe vera gel is recommended as the treatment of choice for surgical incisions.

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Section: Discussionmentioning

confidence: 99%

“…A topical T3 (tri-iodothyronine) cream was prepared by dissolving 150-ng of T3 (Sigma, Barcelona, Spain) in 20 µl of ethanol and then mixed it into vehicle (V) [24, 25]. We purchased SSD cream from Sobhan Daru Co. (Tehran, Iran).…”

Section: Methodsmentioning

confidence: 99%

Aloe vera gel and thyroid hormone cream may improve wound healing in Wistar rats

et al. 2012

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“…A greenish gel-like liquid was obtained which was further refined through the use of a strainer. We also prepared a topical T3 cream by dissolving 150-ng of T3 (Sigma, made in Spain) in 20 µL of ethanol and then mixed it into the vehicle [29,30]. Silver sulfadiazine was purchased from Sobhan Daru Co. as a synthetic cream.…”

Section: Methodsmentioning

confidence: 99%

A comparative study of the effects of topical application ofAloe vera,thyroid hormoneandsilver sulfadiazineon skin wounds inWistarrats

et al. 2012

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Many research studies report the healing effects of Aloe Vera, thyroid hormone cream and silver sulfadiazine. However, the effects of these therapeutic agents are not well understood and have not been compared in one study. This study aimed at investigating the effects of topical application of an Aloe vera gel, a thyroid hormone cream and a silver sulfadiazine cream on the healing of skin wounds surgically induced in Wistar rats for determining the treatment of choice. In a randomized controlled trial, twelve male rats, aged 120 days and with a mean weight of 250 to 300 g, were divided randomly into 5 groups based on drug treatments: Aloe vera gel (AV), thyroid hormone cream (TC), silver sulfadiazine 1% (S), vehicle (V) and control. To evaluate the efficacy of each treatment technique, a biomechanical approach was used to assess tensile stress after 14 days of treatment. Tensile stress was significantly improved in the Aloe vera gel group as compared with the other four groups (P≤0.05). While the other treatment options resulted in better healing than the control group, this difference was not significant. We conclude that Aloe vera topical application accelerated the healing process more than thyroid hormone, silver sulfadiazine and vehicle in surgically induced incisions in rats.

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“…77 Early greying has been claimed to be related to autoimmune thyroid disease, and both hypo-and hyperthyroidism, 78 whereas re-pigmentation of previously grey/white hair has been reported in some patients under systemic T4 therapy. 79…”

Section: F I G U R Ementioning

confidence: 99%

“…Yet, patients with frontal fibrosing alopecia reportedly have more often associated thyroid disorders than is generally seen in the European population 77 . Early greying has been claimed to be related to autoimmune thyroid disease, and both hypo‐ and hyperthyroidism, 78 whereas re‐pigmentation of previously grey/white hair has been reported in some patients under systemic T4 therapy 79 …”

Section: Clinical Pointers To Thyroid Hormones As Major Modulators Ofmentioning

confidence: 99%

Topical L‐thyroxine: The Cinderella among hormones waiting to dance on the floor of dermatological therapy?

Paus

Ramot

Kirsner

et al. 2020

Experimental Dermatology

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Dermatologists have used natural or synthetic agonists of glucocorticoid, vitamin D or retinoid nuclear hormone receptors, both systemically and topically, for decades in the management of skin diseases. In fact, the introduction of glucocorticoids, calcitriols and retinoids into the clinic each constituted landmark progress in skin therapies, and the range of dermatological indications for each of these distinct classes of chemicals rapidly expanded after they became widely accepted in clinical practice. 1,2 Given the success of these agents, it is surprising that a fourth class of potent nuclear hormone receptor agonists has not been developed as part of the therapeutic arsenal of dermatology: endogenous and synthetic thyroid hormone receptor (TR) ligands. 3 This "Cinderella status" of these peptide hormones among endocrinological dermatotherapy is even more surprising in view of

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Repigmentación del pelo canoso tras tratamiento con hormona tiroidea

Cited by 22 publications

References 41 publications

Aloe vera gel and thyroid hormone cream may improve wound healing in Wistar rats

Aloe vera gel and thyroid hormone cream may improve wound healing in Wistar rats

A comparative study of the effects of topical application ofAloe vera,thyroid hormoneandsilver sulfadiazineon skin wounds inWistarrats

Topical L‐thyroxine: The Cinderella among hormones waiting to dance on the floor of dermatological therapy?

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