Repigmentation and curling of hair after acitretin therapy

Seçkin, Dilek; Yildiz, Ayfer

doi:10.1111/j.1440-0960.2009.00542.x

Cited by 40 publications

(33 citation statements)

References 16 publications

(30 reference statements)

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“…There is no original work in the available literature which has reported the effects of isotretinoin on hair. Individual studies indicate that acitretin often causes hair loss [38, 39] and Seckin and Yildiz [40] reported a change in the color and structure of the hair. A decrease in the proportion of anagen hair observed in our patients can appeal for telogen effluvium hair loss.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of biophysical skin parameters and assessment of hair growth in patients with acne treated with isotretinoin

Kmieć¹,

Pajor²,

Broniarczyk-Dyła³

2013

pdia

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IntroductionTreatment of the severe forms of acne vulgaris remains a challenge. Isotretinoin is a drug often used in these cases. Retinoids affect the mechanisms that play a role in the pathogenesis of acne, reduce the production of sebum and sizes of the sebaceous glands. However, isotretinoin appears to have undesirable side effects in the skin, mucous membranes and hair.AimThe aim of this study was to assess the effect of acne vulgaris treatment with isotretinoin on biophysical skin parameters: skin sebum and stratum corneum hydration levels, transepidermal water loss values, pH, erythema and hair growth parameters: total number, density and proportion of anagen hair.Material and methodsThe study included thirty patients with acne types: papulopustular, conglobata and phlegmonosa. Patients were treated with isotretinoin at a dose of 0.5–1.0 mg/kg/day for a period of 4–7 months. The measurements of skin biophysical parameters were performed before and after the treatment using Sebumeter SM815, Corneometer CM825, Tewameter TM300, MX Mexameter MX18 and Skin-pH-Meter PH908. Hair growth parameters were evaluated with FotoFinder Dermoscope using the TrichoScan Professional V3.0.8.76 software.ResultsThe results of biophysical skin parameter measurements after the treatment showed a reduction in the severity of seborrhea. However, the skin was dry, which confirmed a lowered degree of stratum corneum hydration and an increase in transepidermal water loss values. Moreover, severity of erythema, an increase in pH value, and variations in selected hair growth parameters: decrease in total count, density and proportion of anagen hair were demonstrated.ConclusionsThe reduction in the skin sebum levels was observed after the treatment. There was dryness of the skin, which was confirmed by biophysical skin parameter measurements. Changes in the hair growth parameters showed telogen effluvium hair loss.

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Section: Discussionmentioning

confidence: 99%

Evaluation of biophysical skin parameters and assessment of hair growth in patients with acne treated with isotretinoin

Kmieć¹,

Pajor²,

Broniarczyk-Dyła³

2013

pdia

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“…[72,73] Darkening of hair has also been reported as an incidental finding with other drugs such as defibrotide, cyclosporine, corticosteroid, etretinate, L-thyroxine, verapamil, tamoxifen, levodopa, cisplatin, acitretin, tri-iodothyronine, and lenalidomide. [71,[74][75][76][77] However, in most of these cases, drug-induced etiology of pigmentation could only be confirmed if hair had returned to its original color after drug withdrawal. The same could not be confirmed as most patients were continued on treatment with the suspected drug.…”

Section: Management Managementmentioning

confidence: 99%

Premature graying of hair

Pandhi¹,

Khanna²

2013

Indian J Dermatol Venereol Leprol

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Premature graying is an important cause of low self-esteem, often interfering with socio-cultural adjustment. The onset and progression of graying or canities correlate very closely with chronological aging, and occur in varying degrees in all individuals eventually, regardless of gender or race. Premature canities may occur alone as an autosomal dominant condition or in association with various autoimmune or premature aging syndromes. It needs to be differentiated from various genetic hypomelanotic hair disorders. Reduction in melanogenically active melanocytes in the hair bulb of gray anagen hair follicles with resultant pigment loss is central to the pathogenesis of graying. Defective melanosomal transfers to cortical keratinocytes and melanin incontinence due to melanocyte degeneration are also believed to contribute to this. The white color of canities is an optical effect; the reflection of incident light masks the intrinsic pale yellow color of hair keratin. Full range of color from normal to white can be seen both along individual hair and from hair to hair, and admixture of pigmented and white hair is believed to give the appearance of gray. Graying of hair is usually progressive and permanent, but there are occasional reports of spontaneous repigmentation of gray hair. Studies evaluating the association of canities with osteopenia and cardiovascular disease have revealed mixed results. Despite the extensive molecular research being carried out to understand the pathogenesis of canities, there is paucity of effective evidence-based treatment options. Reports of repigmentation of previously white hair following certain inflammatory processes and use of drugs have suggested the possibility of cytokine-induced recruitment of outer sheath melanocytes to the hair bulb and rekindled the hope for finding an effective drug for treatment of premature canities. In the end, camouflage techniques using hair colorants are outlined.

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“…Kinking of the hair (in addition to pigmentation changes) has also been reported with the use of acitretin and etretinate, which are thought to be associated with a change in keratinization patterns within the inner root sheath. 17,18 To our knowledge, this is the first report of a patient with AA who experienced a change in hair structure that recapitulated the patient's hair texture as a child. The precipitating factor for this change may have been a result of treatment of AA, pathophysiologic changes associated with the AA, or a combination of both.…”

Section: Commentmentioning

confidence: 75%