Repigmentation of hypopigmented scars using combination of fractionated carbon dioxide laser with topical latanoprost vs. fractionated carbon dioxide laser alone

Siadat, Amir Hossein; Rezaei, Reza; Asilian, Ali; Abtahi‐Naeini, Bahareh; Rakhshanpour, Mehrdad; Raei, Mehdi; Hosseini, Seyed Mohsen

doi:10.4103/0019-5154.160481

Cited by 16 publications

(10 citation statements)

References 20 publications

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“…Within dyschromic scars, hypopigmented areas contain the same number of melanocytes as surrounding hyperpigmented or normally pigmented scar tissue, suggesting that hypopigmentation results from a mechanism other than melanocyte deficiency . Both AFR and NAFR improve the color and texture of hypopigmented scars . Adding a topical prostaglandin analog can further enhance repigmentation of hypopigmented scars .…”

Section: Laser Treatment Of Scarsmentioning

confidence: 99%

“…Both AFR and NAFR improve the color and texture of hypopigmented scars . Adding a topical prostaglandin analog can further enhance repigmentation of hypopigmented scars . AFR is more effective at improving hypopigmented scars when utilized at safe settings.…”

Section: Laser Treatment Of Scarsmentioning

confidence: 99%

“…Prostaglandin analogs (e.g., latanoprost, bimatoprost) are used in ophthalmic solutions to reduce intraocular pressure in open‐angle glaucoma and ocular hypertension. They also increase eyelash growth and stimulate melanogenesis . In prostaglandin analog‐treated skin, pigmentation results from an increase in melanin granules without melanocyte proliferation, melanocyte atypia or an inflammatory reaction (Kapur).…”

Section: Laser Treatment Of Scarsmentioning

confidence: 99%

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Laser Therapy of Traumatic and Surgical Scars and an Algorithm for Their Treatment

et al. 2019

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Background and Objectives: This paper describes the laser techniques available for the treatment of surgical and trauma scars and develops recommendations for an algorithmic-based treatment approach based on extensive clinical experience and published data. Study Design/Materials and Methods: We reviewed the literature regarding laser treatment of surgical and traumatic scars and incorporated the clinical experience of the authors to develop an algorithm for the treatment of surgical and trauma scars. Results: In order to develop treatment recommendations, scars were differentiated based on their clinical characteristics. Specific scar characteristics aid in determining the appropriate treatment strategy for different types of complex surgical and trauma scars. Conclusion: Laser therapy is first-line therapy for traumatic and surgical scars. The treatment approach should be guided by scar characteristics (e.g., anatomic location, type of injury, color, thickness, tension, scar age, and activity) and involves choosing the appropriate laser type and determining the benefit of combination therapy with surgical and nonsurgical treatment modalities to optimize treatment responses. Lasers Surg. Med.

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Section: Laser Treatment Of Scarsmentioning

confidence: 99%

Section: Laser Treatment Of Scarsmentioning

confidence: 99%

Section: Laser Treatment Of Scarsmentioning

confidence: 99%

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Laser Therapy of Traumatic and Surgical Scars and an Algorithm for Their Treatment

et al. 2019

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“…In total, 48 published studies of AF LADD met inclusion criteria (eFigure in the Supplement): 4 cosmetic studies,, 21 oncologic, and 23 medical (not cosmetic/oncologic) . In addition, 6 publications of NAF LADD were included at the request of the expert panel, for a total of 54 studies.…”

Section: Resultsmentioning

confidence: 99%

“…Abbreviation: GRADE, Grading of Recommendations Assessment, Development and Evaluation. a These are provided for illustrative purposes and are based on published reports b Level of evidence and strength of recommendation were determined by the guideline panel for the specific indication, but not necessarily for a particular technique or topical agent.…”

Section: Resultsmentioning

confidence: 99%

Evidence-Based Clinical Practice Guidelines for Laser-Assisted Drug Delivery

et al. 2022

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ImportanceLaser-assisted drug delivery (LADD) is used for various medical and cosmetic applications. However, there is insufficient evidence-based guidance to assist clinicians performing LADD.ObjectiveTo develop recommendations for the safe and effective use of LADD.Evidence ReviewA systematic literature review of Cochrane Central Register of Controlled Trials, Embase, and MEDLINE was conducted in December 2019 to identify publications reporting research on LADD. A multidisciplinary panel was convened to draft recommendations informed by the systematic review; they were refined through 2 rounds of Delphi survey, 2 consensus meetings, and iterative review by all panelists until unanimous consensus was achieved.FindingsOf the 48 published studies of ablative fractional LADD that met inclusion criteria, 4 were cosmetic studies; 21, oncologic; and 23, medical (not cosmetic/oncologic), and 6 publications of nonablative fractional LADD were included at the request of the expert panel, producing a total of 54 studies. Thirty-four studies (63.0%) were deemed to have low risk of bias, 17 studies (31.5%) had moderate risk, and 3 (5.5%) had serious risk. The key findings that informed the guidelines developed by the expert panel were as follows: LADD is safe in adults and adolescents (≥12 years) with all Fitzpatrick skin types and in patients with immunosuppression; it is an effective treatment for actinic keratosis, cutaneous squamous cell carcinoma in situ, actinic cheilitis, hypertrophic scars, and keloids; it is useful for epidermal and dermal analgesia; drug delivery may be increased through the application of heat, pressure, or occlusion, or by using an aqueous drug solution; laser settings should be selected to ensure that channel diameter is greater than the delivered molecule; antibiotic prophylaxis is not recommended, except with impaired wound healing; antiviral prophylaxis is recommended when treating the face and genitalia; and antifungal prophylaxis is not recommended. The guideline’s 15 recommendations address 5 areas of LADD use: (I) indications and contraindications; (II) parameters to report; (III) optimization of drug delivery; (IV) safety considerations; and (V) prophylaxis for bacterial, viral, and fungal infections.Conclusions and RelevanceThis systematic review and Delphi consensus approach culminated in an evidence-based clinical practice guideline for safe and effective use of LADD in a variety of applications. Future research will further improve our understanding of this novel treatment technique.

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Fractional resurfacing in the Asian patient: Current state of the art

Wat

Chan

2016

Lasers Surg Med

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Taking into account the unique characteristics and cosmetic concerns of the Asian population, fractional resurfacing can be considered a safe and effective option for the treatment of atrophic and hypertrophic scarring, and photorejuvenation in ethnic skin types. Select cases of melasma may be treated with fractionated non-ablative devices, but utilized with caution. The predominant complication associated with fractional resurfacing for these conditions is post-inflammatory hyperpigmentation (PIH) and rebound worsening of melasma. A greater number of treatments at lower density settings and wider treatment intervals typically produce the lowest risks of PIH without compromising treatment efficacy. Lasers Surg. Med. 49:45-59, 2017. © 2016 Wiley Periodicals, Inc.

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Repigmentation of hypopigmented scars using combination of fractionated carbon dioxide laser with topical latanoprost vs. fractionated carbon dioxide laser alone

Cited by 16 publications

References 20 publications

Laser Therapy of Traumatic and Surgical Scars and an Algorithm for Their Treatment

Laser Therapy of Traumatic and Surgical Scars and an Algorithm for Their Treatment

Evidence-Based Clinical Practice Guidelines for Laser-Assisted Drug Delivery

Fractional resurfacing in the Asian patient: Current state of the art

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