Replacement of osteochondral defect of large joints: An experimental model in sheep

Abstract

To improve the treatment results of patients with osteochondral defects of large joints. Materials and methods: A prospective study was conducted on 30 animals (60 knee joints) aged 1.5-3 years. All animals were divided into 3 groups of 10 each, depending on the method of replacement of the osteo-chondral defect. Results: 6 months after intervention using the proposed method, a good prognosis can be given and good long-term results expected despite the full axial load on the joint a few hours after the operation.

Biphasic Double-Network Hydrogel With Compartmentalized Loading of Bioactive Glass for Osteochondral Defect Repair

“…Just like the progression of osteoarthritis, cartilage loss could occur in the same regions of the joint with the changes in subchondral bone ( Goldring and Goldring, 2016 ). Currently, in order to overcome the limitations of the existing treatments as mentioned above, scaffold-based method is gradually emerging as a hopeful alternative and taking positive effects in repairing osteochondral defects ( McCarrel et al, 2017 ; Rai et al, 2017 ; Saltzman and Riboh, 2018 ; Airapetov et al, 2019 ). In particular, multifunctional biphasic scaffold, which is composed of a cartilage phase and a subchondral bone phase, has attracted more attentions due to its appropriate and adjustable properties for each specific environment ( Ruan et al, 2017 ; Zhang et al, 2017 ; Nie et al, 2019 ).…”