Replacing sedentary time with physical activity and sleep: associations with quality of life in kidney cancer survivors

Tabaczynski, Allyson; Courneya, Kerry S.; Trinh, Linda

doi:10.1007/s10552-020-01308-x

Cited by 12 publications

(12 citation statements)

References 60 publications

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“…In accordance with our hypotheses, reallocating sedentary time to either LPA or MVPA was beneficial in terms of lower fatigue, with the reallocation to MVPA having the greatest effects. This is somewhat in line with the results from two previous studies, using isotemporal substitution with data from 463 kidney cancer survivors [ 34 ] and 149 non-Hodgkin lymphoma survivors [ 35 ]. In both studies, the authors found that reallocating sedentary time to MVPA was associated with lower fatigue, whilst one of the studies [ 34 ] also reported such effects when reallocating sedentary time to LPA.…”

Section: Discussionsupporting

confidence: 92%

“…This is somewhat in line with the results from two previous studies, using isotemporal substitution with data from 463 kidney cancer survivors [ 34 ] and 149 non-Hodgkin lymphoma survivors [ 35 ]. In both studies, the authors found that reallocating sedentary time to MVPA was associated with lower fatigue, whilst one of the studies [ 34 ] also reported such effects when reallocating sedentary time to LPA. However, the amounts of time reallocation necessary to reach minimally clinical changes were lower compared to our findings: 65 min/day for LPA and 83 min/day for MVPA in the study of Tabaczynski et al [ 34 ] and 30 min/day for MVPA in the study of Vallance et al [ 35 ].…”

Section: Discussionsupporting

confidence: 92%

“…In both studies, the authors found that reallocating sedentary time to MVPA was associated with lower fatigue, whilst one of the studies [ 34 ] also reported such effects when reallocating sedentary time to LPA. However, the amounts of time reallocation necessary to reach minimally clinical changes were lower compared to our findings: 65 min/day for LPA and 83 min/day for MVPA in the study of Tabaczynski et al [ 34 ] and 30 min/day for MVPA in the study of Vallance et al [ 35 ]. This discrepancy between the results from the above-mentioned studies and ours could be explained by the methodology used (fatigue was assessed with different questionnaires), the study samples having different cancer diagnoses and the timing of the assessments (prior to adjuvant treatment vs. post-treatment).…”

Section: Discussionmentioning

confidence: 99%

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Reallocating sedentary time to physical activity: effects on fatigue and quality of life in patients with breast cancer in the Phys-Can project

Mazzoni

Strandberg

Börjeson

et al. 2023

Support Care Cancer

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Purpose We aimed to investigate the effects of reallocating sedentary time to an equal amount of light (LPA) or moderate-to-vigorous intensity physical activity (MVPA) on cancer-related fatigue and health-related quality of life (HRQoL) in patients with breast cancer. We also aimed to determine the daily amount of sedentary time needed to be reallocated to LPA or MVPA to produce minimal clinically important changes in these outcomes. Methods Pooled baseline data from three studies were used, including women with breast cancer who participated in the Phys-Can project. Fatigue was assessed with the Multidimensional Fatigue Inventory questionnaire (MFI; five dimensions, 4–20 scale) and HRQoL with the European Organisation for Research and Treatment of Cancer quality of life questionnaire (EORTC QLQ-C30; 0–100 scale). Sedentary time and physical activity were measured with accelerometry. Isotemporal substitution modelling was used for the analyses. Results Overall, 436 participants (mean age 56 years, fatigue 11 [MFI], HRQoL 66 [EORTC QLQ-C30], LPA 254 min/day, MVPA 71 min/day) were included. Fatigue significantly decreased in two MFI dimensions when reallocating 30 min/day of sedentary time to LPA: reduced motivation and reduced activity (β = − 0.21). Fatigue significantly decreased in three MFI dimensions when reallocating 30 min/day of sedentary time to MVPA: general fatigue (β = − 0.34), physical fatigue (β = − 0.47) and reduced activity (β = − 0.48). To produce minimal clinically important changes in fatigue (− 2 points on MFI), the amount of sedentary time needed to be reallocated to LPA was ≈290 min/day and to MVPA was ≥ 125 min/day. No significant effects were observed on HRQoL when reallocating sedentary time to LPA or MVPA. Conclusions Our results suggest that reallocating sedentary time to LPA or MVPA has beneficial effects on cancer-related fatigue in patients with breast cancer, with MVPA having the greatest impact. In relatively healthy and physically active breast cancer populations, a large amount of time reallocation is needed to produce clinically important changes. Future studies are warranted to evaluate such effects in broader cancer populations. Trial registration: NCT02473003 (10/10/2014) and NCT04586517 (14/10/2020).

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

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Reallocating sedentary time to physical activity: effects on fatigue and quality of life in patients with breast cancer in the Phys-Can project

Mazzoni

Strandberg

Börjeson

et al. 2023

Support Care Cancer

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“…The 10-min bouts of PA which we reallocated in our study may be more realistic for sedentary individuals to adopt, at least initially, if a concerted effort is made to adopt a healthier lifestyle. Other studies using isotemporal substitution modeling have shown the benefits of reallocating sedentary for active behavior for improving aspects of health-related quality of life in 145 patients with lymphoma [53], and fatigue and quality of life in 753 patients with breast cancer [54]. Isotemporal substitution modeling has also been used to identify clinically important minimal thresholds; for example, reallocating ~ 65 min per day of sedentary time to light PA was associated with clinically meaningful improvements in fatigue in 463 kidney cancer survivors [55].…”

Section: Discussionmentioning

confidence: 99%

Substituting bouts of sedentary behavior with physical activity: adopting positive lifestyle choices in people with a history of cancer

Ingle

Ruilova

Cui

et al. 2022

Cancer Causes Control

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Purpose To determine in people with a history of cancer, whether substituting sitting time with other daily activities (i.e., sleeping, walking, moderate and vigorous physical activity) was associated with changes in waist circumference (WC), an important surrogate marker of cardiometabolic risk. Methods Cross-sectional analyses from the Atlantic Partnership for Tomorrow’s Health (Atlantic PATH) cohort was conducted using isotemporal substitution models to explore the associations of substituting sedentary time, physical activity behavior (International Physical Activity Questionnaire), or sleep (Pittsburgh Sleep Quality Index) with changes in WC. Analyses were conducted using sex-specific WC classifications. Results In 3,684 people with a history of cancer [mean age (SD) 58.2 (7.3) years; BMI 28.9 (5.2) kg m−2; 71% female], reallocating 10 min of sleep or sedentary time for 10 min of walking was associated with lower WC in women (p < 0.01). In men, PA intensity appeared to be more strongly associated with a reduced WC. Replacing 10 min of sedentary time with 10 min of moderate or vigorous PA and replacing 10 min of sleep with moderate PA were associated with a significantly reduced WC (p < 0.001). The largest effect was when 10 min of moderate PA was replaced with vigorous PA, a reduction in WC (p < 0.01) was evident. Conclusion For people with a history of cancer, adopting small but positive changes in lifestyle behaviors could help reduce WC and potentially offset negative health-related outcomes associated with higher WC. Further research is required to examine whether such an intervention may be acceptable and manageable among this population.

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“…In multivariate analyses of 222,163 individuals, "any physical activity" was associated with 50% fewer kidney cancer deaths than that seen in nonexercisers [95]. Exercise improves QOL in kidney cancer patients [96].…”

Section: Exercise and Kidney Cancermentioning

confidence: 97%

Exercise: Preventive and Therapeutic Benefits in Cancer

Agarwal¹

2021

J. Can. Res. Updates

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Cancer is soon expected to overtake cardiovascular diseases as the leading cause of death in the world. As newer and often more expensive cancer treatments become available, several complementary modalities are gaining clinical importance. Exercise is one such modality. Increasing scientific data suggests that exercise, besides helping prevent several cancers, can also help improve outcomes across a range of cancer diagnoses. The mechanisms behind this protection and therapeutic effects are numerous and include changes in body composition, insulin sensitivity, oxidative stress, sex hormone levels, systemic inflammation, immune cell function, and DNA integrity. Exercise is easy to do, is inexpensive, and can be modified to the condition of the patient. This review summarizes the various benefits of structured activity in most major cancers affecting humans.

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Replacing sedentary time with physical activity and sleep: associations with quality of life in kidney cancer survivors

Cited by 12 publications

References 60 publications

Reallocating sedentary time to physical activity: effects on fatigue and quality of life in patients with breast cancer in the Phys-Can project

Reallocating sedentary time to physical activity: effects on fatigue and quality of life in patients with breast cancer in the Phys-Can project

Substituting bouts of sedentary behavior with physical activity: adopting positive lifestyle choices in people with a history of cancer

Exercise: Preventive and Therapeutic Benefits in Cancer

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