Replicability of Treatment Effect in Study of Blood Pressure Lowering With Dementia

Panagiotou, Orestis A.; Jaljuli, Iman; Heller, Ruth

doi:10.1001/jama.2020.14871

JAMA

2020

DOI: 10.1001/jama.2020.14871

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Replicability of Treatment Effect in Study of Blood Pressure Lowering With Dementia

Orestis A. Panagiotou

Iman Jaljuli

Ruth Heller

Abstract: colic, which supported ultrasonography in younger patients and middle-aged patients with a history of kidney stones. 5 We suggest that the risks and benefits of each imaging test be tailored to individual patients, and using ultrasonography first when appropriate may prevent exposing patients to the unnecessary risks of routine CT.

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Cited by 2 publications

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Closing the Gap Between Observational Research and Randomized Controlled Trials for Prevention of Alzheimer Disease and Dementia

Power¹,

Engelman²,

Wei³

et al. 2022

Epidemiologic Reviews

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Although observational studies have identified modifiable risk factors for Alzheimer’s disease and related dementias (ADRD), randomized controlled trials (RCTs) of risk factor modification for ADRD prevention have been inconsistent or inconclusive. This suggests a need to improve translation between observational studies and RCTs. However, many common features of observational studies reduce their relevance to designing related RCTs. Observational studies routinely differ from RCTs with respect to eligibility criteria, study population, length of follow-up, treatment conditions, outcomes, and effect estimates. Using the motivating example of blood pressure reduction for ADRD prevention, we illustrate the need for a tighter connection between observational studies and RCTs, discuss barriers to using typically-reported observational evidence in developing RCTs, and highlight methods that may be used to make observational research more relevant to clinical trial design. We conclude that the questions asked and answered by observational research can be made more relevant to clinical trial design, and that better use of observational data may increase the likelihood of successful, or at least definitive, trials. While we focus on improving translation of observational studies on risk factors for ADRD to RCTs in ADRD prevention, the overarching themes are broadly applicable to many areas of biomedical research.

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Closing the Gap Between Observational Research and Randomized Controlled Trials for Prevention of Alzheimer Disease and Dementia

Power¹,

Engelman²,

Wei³

et al. 2022

Epidemiologic Reviews

View full text Add to dashboard Cite

show abstract

Replicability Across Multiple Studies

Bogomolov,

Heller

2023

Statist. Sci.

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Replicability of Treatment Effect in Study of Blood Pressure Lowering With Dementia

Cited by 2 publications

References 7 publications

Closing the Gap Between Observational Research and Randomized Controlled Trials for Prevention of Alzheimer Disease and Dementia

Closing the Gap Between Observational Research and Randomized Controlled Trials for Prevention of Alzheimer Disease and Dementia

Replicability Across Multiple Studies

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