2002
DOI: 10.1128/jvi.76.23.12069-12077.2002
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Replication Advantage and Host Factor-Independent Phenotypes Attributable to a Common Naturally Occurring Capsid Mutation (I97L) in Human Hepatitis B Virus

Abstract: Mutations of human hepatitis B virus (HBV) occur frequently within the capsid (core) protein in natural infections. The most frequent mutation of the core protein in HBV from Southeast Asia occurs at amino acid 97, changing an isoleucine (I) to a leucine (L). In our systematic study of virus-host interactions, we have examined the replication efficiency of a site-directed mutant, I97L, and its parental wild-type HBV in several different hepatoma cell lines. Interestingly, we found that this capsid variant repl… Show more

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Cited by 41 publications
(42 citation statements)
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“…1B). To confirm the identity of the expressed and purified HBcAg, we performed immunoblot analysis with a rabbit polyclonal anti-core antibody (27). Both monomeric and dimeric HBcAg1-149 can be detected by immunological crossreactivity using Western blot analysis (right panel, Fig.…”
Section: Resultsmentioning
confidence: 99%
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“…1B). To confirm the identity of the expressed and purified HBcAg, we performed immunoblot analysis with a rabbit polyclonal anti-core antibody (27). Both monomeric and dimeric HBcAg1-149 can be detected by immunological crossreactivity using Western blot analysis (right panel, Fig.…”
Section: Resultsmentioning
confidence: 99%
“…Despite the prevalence of this mutation reported by many different research groups (see references in Suk et al [27]), the functional significance of this hotspot mutation remains to be investigated. Previously, we noted two distinct phenotypes associated with this core mutation.…”
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confidence: 99%
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“…Mutation of amino acid 97 to leucine, one of the most common mutations of the core protein seen in chronic infections (13), has been found to affect nucleic acid metabolism (26,(35)(36)(37). Depending on the strain of HBV, residue 97 is phenylalanine (e.g., ayw and adyw) or isoleucine (e.g., adr and adw).…”
mentioning
confidence: 99%