2022
DOI: 10.1101/2022.12.21.521484
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Replication in the presence of dengue convalescent serum impacts Zika virus neutralization sensitivity and fitness

Abstract: Flaviviruses like dengue virus (DENV) and Zika virus (ZIKV) are mosquito-borne viruses that cause febrile, hemorrhagic, and neurological diseases in humans, resulting in 400 million infections annually. Due to their co-circulation in many parts of the world, flaviviruses must replicate in the presence of pre-existing adaptive immune responses targeted at serologically closely related pathogens, which can provide protection or enhance disease. However, the impact of pre-existing cross-reactive immunity as a dri… Show more

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“…Serotipe DENV yang paling umum di Indonesia adalah DENV-2 dan DENV-3, dengan DENV-3 menyumbang sebagian besar kasus parah (Abinawanto et al, 2020). Menurut penelitian tentang pergantian yang terbukti dalam dominasi serotipe dan bukti pertukaran genotipe dalam setiap serotipe, dominasi serotipe DENV tidak konstan (Marano et al, 2023). Prevalensi DENV-4, yang sebelumnya jarang diamati selama wabah demam berdarah di Indonesia, diamati selama wabah demam berdarah 2019 terbaru di daerah Jember Jawa Timur, Indonesia (Aryati et al, 2020).…”
unclassified
“…Serotipe DENV yang paling umum di Indonesia adalah DENV-2 dan DENV-3, dengan DENV-3 menyumbang sebagian besar kasus parah (Abinawanto et al, 2020). Menurut penelitian tentang pergantian yang terbukti dalam dominasi serotipe dan bukti pertukaran genotipe dalam setiap serotipe, dominasi serotipe DENV tidak konstan (Marano et al, 2023). Prevalensi DENV-4, yang sebelumnya jarang diamati selama wabah demam berdarah di Indonesia, diamati selama wabah demam berdarah 2019 terbaru di daerah Jember Jawa Timur, Indonesia (Aryati et al, 2020).…”
unclassified