Replication of equid herpesvirus-1 (EHV-1) in the testes and epididymides of ponies and venereal shedding of infectious virus

Tearle, J.P.; Smith, Ken; Boyle, M.S.; Binns, M. M.; Livesay, Georgia; Mumford, J. A.

doi:10.1016/s0021-9975(96)80073-9

Cited by 28 publications

(32 citation statements)

References 23 publications

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“…Equine herpesvirus-1 DNA has been isolated from semen collected from clinically normal stallions that had been experimentally infected, although venereal spread resulting in infection of susceptible mares has not yet been proven. 13,14 Evidence of EHV-1 DNA in a racehorse supports the current practice on the farm of segregating pregnant mares from racehorses.…”

Section: Discussionmentioning

confidence: 65%

Prevalence of equine herpesvirus-1 infection among Thoroughbreds residing on a farm on which the virus was endemic

Brown

Mapes

Ball

et al. 2007

javma

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Section: Discussionmentioning

confidence: 65%

Prevalence of equine herpesvirus-1 infection among Thoroughbreds residing on a farm on which the virus was endemic

Brown

Mapes

Ball

et al. 2007

javma

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“…Equine herpesvirus 1 was found to replicate in the testes of ponies and to be shed into semen (323). Endothelial cells are the main testicular target cells of this virus, and there is associated necrotizing vasculitis and thrombosis, but no productive viral infection of the seminiferous epithelium (323).…”

Section: The Animal Testismentioning

confidence: 99%

“…Endothelial cells are the main testicular target cells of this virus, and there is associated necrotizing vasculitis and thrombosis, but no productive viral infection of the seminiferous epithelium (323). Venereal shedding may thus be facilitated by focal tissue ischemia and leakage of free virus of infected cells across the disrupted blood-testis barrier.…”

Section: The Animal Testismentioning

confidence: 99%

Viruses in the Mammalian Male Genital Tract and Their Effects on the Reproductive System

Dejucq

Jégou

2001

Microbiol Mol Biol Rev

290

220

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This review describes the various viruses identified in the semen and reproductive tracts of mammals (including humans), their distribution in tissues and fluids, their possible cell targets, and the functional consequences of their infectivity on the reproductive and endocrine systems. The consequences of these viral infections on the reproductive tract and semen can be extremely serious in terms of organ integrity, development of pathological and cancerous processes, and transmission of diseases. Furthermore, of essential importance is the fact that viral infection of the testicular cells may result not only in changes in testicular function, a serious risk for the fertility and general health of the individual (such as a fall in testosteronemia leading to cachexia), but also in the possible transmission of virus-induced mutations to subsequent generations. In addition to providing an exhaustive account of the data available in these domains, this review focuses attention on the fact that the interface between endocrinology and virology has so far been poorly explored, particularly when major health, social and economical problems are posed. Our conclusions highlight the research strategies that need to be developed. Progress in all these domains is essential for the development of new treatment strategies to eradicate viruses and to correct the virus-induced dysfunction of the endocrine system

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“…Rien n'est connu sur le devenir de tels virus dans l'ovocyte humain. Le VHS1 est également présent chez les animaux, ce qui permet une approche expérimentale [62,63]. En général, l'ovocyte et l'embryon bovins sont protégés d'une infection virale par la zone pellucide jusqu'au stade blastocyste [64,65].…”

Section: Virus Herpes Simplex De Typeunclassified

Transmission virale et assistance médicale à la procréation : le cas des Herpesviridae

Courtot

Pallier

Testart

2004

Gynécologie Obstétrique & Fertilité

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Replication of equid herpesvirus-1 (EHV-1) in the testes and epididymides of ponies and venereal shedding of infectious virus

Cited by 28 publications

References 23 publications

Prevalence of equine herpesvirus-1 infection among Thoroughbreds residing on a farm on which the virus was endemic

Prevalence of equine herpesvirus-1 infection among Thoroughbreds residing on a farm on which the virus was endemic

Viruses in the Mammalian Male Genital Tract and Their Effects on the Reproductive System

Transmission virale et assistance médicale à la procréation : le cas des Herpesviridae

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