Replication of SARS-CoV-2 in adipose tissue determines organ and systemic lipid metabolism in hamsters and humans

Zickler, Martin; Stanelle-Bertram, Stephanie; Ehret, Sandra; Heinrich, Fabian; Lange, Philine; Schaumburg, Berfin; Kouassi, Nancy Mounogou; Beck, Sebastian; Jaeckstein, Michelle Y.; Mann, Oliver; Krasemann, Susanne; Schroeder, Maria; Jarczak, Dominik; Nierhaus, Axel; Kluge, Stefan; Peschka, Manuela; Schlüter, Hartmut; Renné, Thomas; Pueschel, Klaus; Kloetgen, Andreas; Scheja, Ludger; Ondruschka, Benjamin; Heeren, Joerg; Ghiaur, Gabriel

doi:10.1016/j.cmet.2021.12.002

Cited by 48 publications

(74 citation statements)

References 12 publications

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“…Viral persistence in adipose tissue. Importantly ,recent reports have demonstrated the presence of SARS-CoV-2 virus in human adipose tissue and the long-term presence of SARS-CoV-2 RNA in tissue samples that lead to evolution of virus-specific antibodies ( Fajnzylber et al, 2020 ; Zickler et al, 2022 ). Martinez-Colon et al identified two cellular targets of SARS-CoV-2 infection in adipose tissue mature adipocytes in adipose depots and macrophages.…”

Section: Metabolic Dysfunction and Pascmentioning

confidence: 99%

Post-acute sequelae of COVID-19: A metabolic perspective

Scherer

Kirwan

Rosen

2022

eLife

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The SARS-CoV-2 pandemic continues to rage around the world. At the same time, despite strong public health measures and high vaccination rates in some countries, a post-COVID-19 syndrome has emerged which lacks a clear definition, prevalence, or etiology. However, fatigue, dyspnea, brain fog, and lack of smell and/or taste are often characteristic of patients with this syndrome. These are evident more than a month after infection, and are labeled as Post-Acute Sequelae of CoV-2 (PASC) or commonly referred to as long-COVID. Metabolic dysfunction (i.e., obesity, insulin resistance, and diabetes mellitus) is a predisposing risk factor for severe acute COVID-19, and there is emerging evidence that this factor plus a chronic inflammatory state may predispose to PASC. In this article, we explore the potential pathogenic metabolic mechanisms that could underly both severe acute COVID-19 and PASC, and then consider how these might be targeted for future therapeutic approaches.

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Section: Metabolic Dysfunction and Pascmentioning

confidence: 99%

Post-acute sequelae of COVID-19: A metabolic perspective

Scherer

Kirwan

Rosen

2022

eLife

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“…To further strengthen these findings, Zickler et al demonstrated SARS-CoV-2 infectivity in differentiated and lipid-laden adipocytes but not preadipocytes or immature precursors [ 23 ]. This results presumably due to an augmented ACE2 membrane expression in the course of adipocyte differentiation, although the authors also ascertained that inhibition of lipid catabolism in mature adipocytes reduced viral replication by a factor of 100-fold and acted so synergistically to atorvastatin, being unclear whether all these effects are mediated via an altered ACE2 expression.…”

mentioning

confidence: 99%

“…Two reports recently published in Cell Metabolism have offered novel evidence to elucidate the underlying link between hyperglycemia and SARS-CoV-2 infection [ 22 , 23 ]. Reiterer et al ascertained the adverse prognostic significance of increased plasma glucose among 3854 individuals hospitalized with COVID-19, whereby the presence of hyperglycemia (defined somewhat arbitrarily as blood glucose >170 mg/dl) was associated with a 15.6-, 9.8- and 3.3-fold elevated risk for intubation, ARDS and death, respectively [ 22 ].…”

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confidence: 99%

“…In line with the findings by Reiterer et al [ 22 ], it was further shown that adipocyte infection with SARS-CoV-2 results in the suppression of genes related to de novo lipogenesis and the induction of immune response-related genes. This is paralleled by a notable reduction of triglycerides containing de novo synthesized fatty acids and a concomitant increase of those with esterified exogenous polyunsaturated fatty acids, hence signifying an impaired dietary fatty acid (FA) metabolism or effectively, an impaired postprandial triglyceridemia, further adding to the frame of a systemic dysmetabolic milieu [ 23 ].…”

mentioning

confidence: 99%

“…Another implication concerns the potential tropism of SARS-CoV-2 for lipid-laden cells and tissues, which was highlighted in the study by Zickler et al [ 23 ]. Based on their findings, this may be at least partly due to the upregulated ACE2 membrane expression.…”

mentioning

confidence: 99%

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SARS-CoV-2 adipose tissue infection and hyperglycemia: A further step towards the understanding of severe COVID-19

Tsilingiris

2022

Metabolism Open

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Numerous studies have highlighted the prognostic significance of hyperglycemia in the outcomes of SARS-CoV-2 infection. A number of mechanisms have been proposed as potential drivers of this association, which were, however, up until recently based rather on speculation than on investigational evidence. It has been recently come to light that the development of insulin resistance in the frame of COVID-19 is likely the driving force behind the development of overt hyperglycemia. This results through the infectious insult of the adipose tissue, and is observed in conjunction with aberrant adipokine secretion by host adipocytes, such as decreased adiponectin, as well as a switch towards an antiviral immune secretory profile. These data could have a considerable relevance not only for the management of hyperglycemia in the course of the infection but also for the overall understanding of the pathogenesis of severe COVID-19.

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Glucose oxidase‐instructed biomineralization of calcium‐based biomaterials for biomedical applications

Sun

et al. 2023

Exploration

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In recent years, glucose oxidase (GOx) has aroused great research interest in the treatment of diseases related to abnormal glucose metabolisms like cancer and diabetes. However, as a kind of endogenous oxido‐reductase, GOx suffers from poor stability and system toxicity in vivo. In order to overcome this bottleneck, GOx is encapsulated in calcium‐based biomaterials (CaXs) such as calcium phosphate (CaP) and calcium carbonate (CaCO3) by using it as a biotemplate to simulate the natural biomineralization process. The biomineralized GOx holds improved stability and reduced side effects, due to the excellent bioactivity, biocompatibitliy, and biodegradability of CaXs. In this review, the state‐of‐the‐art studies on GOx‐mineralized CaXs are introduced with an emphasis on their application in various biomedical fields including disease diagnosis, cancer treatment, and diabetes management. The current challenges and future perspectives of GOx‐mineralized CaXs are discussed, which is expected to promote further studies on these smart GOx‐mineralized CaXs biomaterials for practical applications.

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Replication of SARS-CoV-2 in adipose tissue determines organ and systemic lipid metabolism in hamsters and humans

Cited by 48 publications

References 12 publications

Post-acute sequelae of COVID-19: A metabolic perspective

Post-acute sequelae of COVID-19: A metabolic perspective

SARS-CoV-2 adipose tissue infection and hyperglycemia: A further step towards the understanding of severe COVID-19

Glucose oxidase‐instructed biomineralization of calcium‐based biomaterials for biomedical applications

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