1995
DOI: 10.1099/0022-1317-76-6-1317
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Replication pattern of human immunodeficiency virus type 1 in mature Langerhans cells

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Cited by 24 publications
(14 citation statements)
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“…Uniform MHC class I expression has been demonstrated on Langerhans cells in prepared cell suspensions, but the necessary disruption of tissues may result in substantial modulation of phenotype. 11,12,14,[16][17][18]45 Mouse bone marrow chimeras were developed in order to abolish immunostaining of keratinocytes in sections stained for MHC class I glycoproteins. 11,12 Briefly, immunodeficient mice were transfused with allogeneic haemopoietic cells.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Uniform MHC class I expression has been demonstrated on Langerhans cells in prepared cell suspensions, but the necessary disruption of tissues may result in substantial modulation of phenotype. 11,12,14,[16][17][18]45 Mouse bone marrow chimeras were developed in order to abolish immunostaining of keratinocytes in sections stained for MHC class I glycoproteins. 11,12 Briefly, immunodeficient mice were transfused with allogeneic haemopoietic cells.…”
Section: Discussionmentioning
confidence: 99%
“…Langerhans cells express CD4 and have been cited as potential targets for HIV. 37,47 Several investigators have demonstrated the presence of HIV virions, 45,48,49 proviral DNA, 50 and RNA transcripts 51 within Langerhans cells. Langerhans cells infected with HIV-1 are defective in their ability to induce a primary immune response 52 and may transmit the virus to the T-cell compartment of lymph nodes.…”
Section: Discussionmentioning
confidence: 99%
“…LC purified from migrating cells of human epidermis explants express CD4, the primary receptor for HIV-1 [31], and coreceptor CCR5 [32, 33], which is required for infection by R5 tropic strains of HIV-1 [34]. Consequently, cultured LC can be productively infected with R5 HIV-1 [35].…”
Section: Langerhans Cells (Lc) Dermal DC (Ddc) and Interdigitatimentioning
confidence: 99%
“…LC were isolated as described [30]. Briefly, human skin was obtained as clinical specimen from corrective plastic surgery.…”
Section: Isolation and Culture Of Mature Langerhans Cellsmentioning
confidence: 99%