Replication the association of 2q32.2–q32.3 and 14q32.11 with hepatocellular carcinoma

Chen, Wei; Wang, Mingquan; Zhang, Zhen; Tang, Huayang; Zuo, Xianbo; Meng, Xiang-Ling; Xiong, Maoming; Zhou, Fusheng; Liang, Bo; Dai, Fang; Fang, Jun; Gao, Jinping; Jun, Zhu; Wan, Hong; Wang, Miaofeng; Chan, Shixin; Sun, Liangdan

doi:10.1016/j.gene.2015.02.006

Cited by 10 publications

(16 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We also tested 7 SNP previously described as associated with HCC risk in GWAS. In the literature, SNP identified in GWAS failed to be validated in other GWAS and in case–control studies available in the literature . Similarly, we failed to confirm an association between these SNP and HCC development except for rs7574865 STAT4 that were linked with HCC occurrence in HBV related HCC in our study, confirming the results of the original GWAS.…”

Section: Discussionsupporting

confidence: 57%

“…Similarly, we failed to confirm an association between these SNP and HCC development except for rs7574865 STAT4 that were linked with HCC occurrence in HBV related HCC in our study, confirming the results of the original GWAS. In this analysis, we did not perform correction for multiple testing because we considered this part of our study as a replication of previous findings . The different results between our study and GWAS studies could be explained by the difference in term of control group (chronic liver disease population vs .…”

Section: Discussionmentioning

confidence: 80%

See 1 more Smart Citation

PNPLA3 and TM6SF2 variants as risk factors of hepatocellular carcinoma across various etiologies and severity of underlying liver diseases

Yang

Trépo

Nahon

et al. 2018

Intl Journal of Cancer

View full text Add to dashboard Cite

Few single nucleotide polymorphisms (SNPs) have been reproducibly associated with hepatocellular carcinoma (HCC). Our aim was to test the association between nine SNPs and HCC occurrence. SNPs in genes linked to HCC (DEPDC5, GRIK1, KIF1B, STAT4, MICA, DLC1, DDX18) or to liver damage (PNPLA3‐rs738409, TM6SF2‐rs58542926) in GWAS were genotyped in discovery cohorts including 1,020 HCC, 2,021 controls with chronic liver disease and 2,484 healthy individuals and replication was performed in prospective cohorts of cirrhotic patients with alcoholic liver disease (ALD, n = 249) and hepatitis C (n = 268). In the discovery cohort, PNPLA3 and TM6SF2 SNPs were associated with HCC (OR = 1.67 [CI95%:1.16–2.40], p = 0.005; OR = 1.45 [CI95%:1.08–1.94], p = 0.01) after adjustment for fibrosis, age, gender and etiology. In contrast, STAT4‐rs7574865 was associated with HCC only in HBV infected patients (p = 0.03) and the other tested SNP were not linked with HCC risk. PNPLA3 and TM6SF2 variants were independently associated with HCC in patients with ALD (OR = 3.91 [CI95%:2.52–6.06], p = 1.14E‐09; OR = 1.79 [CI95%:1.25–2.56], p = 0.001) but not with other etiologies. PNPLA3 SNP was also significantly associated with HCC developed on a nonfibrotic liver (OR = 2.19 [CI95%:1.22–3.92], p = 0.007). The association of PNPLA3 and TM6SF2 with HCC risk was confirmed in the prospective cohort with ALD. A genetic score including PNPLA3 and TM6SF2 minor alleles showed a progressive significant increased risk of HCC in ALD patients. In conclusion, PNPLA3‐rs738409 and TM6SF2‐rs58542926 are inherited risk variants of HCC development in patients with ALD in a dose dependent manner. The link between PNPLA3 and HCC on nonfibrotic liver suggests a direct role in liver carcinogenesis.

show abstract

Section: Discussionsupporting

confidence: 57%

Section: Discussionmentioning

confidence: 80%

PNPLA3 and TM6SF2 variants as risk factors of hepatocellular carcinoma across various etiologies and severity of underlying liver diseases

Yang

Trépo

Nahon

et al. 2018

Intl Journal of Cancer

View full text Add to dashboard Cite

show abstract

“…Therefore, as shown in Table , 14 populations were studied with regard to STAT4 rs7574865 polymorphism with a total of 7503 HCC patients (cases) and 13 831 individuals without HCC (controls). Among 14 populations, almost all HCC patients were affected by HBV, with only 93 HCC patients were not affected by HBV . The genotype distribution in individuals without HCC (controls) was consistent with HWE for all of the selected studies, except for one study, from which only allelic information was extracted …”

Section: Resultsmentioning

confidence: 57%

“…The search strategy retrieved 35 potentially relevant studies. According to the inclusion criteria, eight studies were identified to assess the association between STAT4 polymorphism and the risk of HCC . A flow chart of the study selection is shown in Figure .…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Meta‐analysis reveals an association between signal transducer and activator of transcription‐4 polymorphism and hepatocellular carcinoma risk

Zhang

Liu

et al. 2016

Hepatology Research

View full text Add to dashboard Cite

show abstract

Genome-wide association study of myofiber type composition traits in a yellow-feather broiler population

Fan,

Shan,

Zhang

et al. 2025

Poultry Science

View full text Add to dashboard Cite

Replication the association of 2q32.2–q32.3 and 14q32.11 with hepatocellular carcinoma

Cited by 10 publications

References 28 publications

PNPLA3 and TM6SF2 variants as risk factors of hepatocellular carcinoma across various etiologies and severity of underlying liver diseases

PNPLA3 and TM6SF2 variants as risk factors of hepatocellular carcinoma across various etiologies and severity of underlying liver diseases

Meta‐analysis reveals an association between signal transducer and activator of transcription‐4 polymorphism and hepatocellular carcinoma risk

Genome-wide association study of myofiber type composition traits in a yellow-feather broiler population

Contact Info

Product

Resources

About