Replicative aging of the yeast does not require DNA replication

Zadrag, Renata; Bartosz, Grzegorz; Biliński, T

doi:10.1016/j.bbrc.2005.05.081

Cited by 15 publications

(20 citation statements)

References 17 publications

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“…An obvious criticism to these results was that they are limited to one pair of strains and they should be confirmed on further cases of different origin. This paper confirms our previous findings on three pairs of isogenic strains consisting of different popular standard laboratory strains [except for D1CSP4-8C which is a cross between the SP-4 strain and its mutant (Zadrag et al 2005)] and their disruptants in antioxidant enzymes, showing considerable differences in the replicative lifespan due to various defects of the antioxidant barrier (lack of CuZn, superoxide dismutase, glutaredoxin 5 and peroxiredoxins 1-5).…”

Section: Introductionsupporting

confidence: 90%

“…2). A similar situation occurs when cell entry into the next cycle is transiently inhibited by treatment with alpha pheromone; also in this case the increase of the volume of the cells drives them to reach faster the limiting cell volume (Zadrag et al 2005).…”

Section: Resultsmentioning

confidence: 96%

“…The volume of yeast mother cell increases unavoidably upon each budding, due to the very nature of budding as a mechanism of reproduction in S. cerevisiae which can reach a size too big to allow for efficient completion of the cell cycle. We demonstrated that inhibition of budding but not of protein synthesis and cell volume growth by pheromone treatment decreases yeast replicative lifespan in a manner inversely related to the volume attained (Zadrag et al 2005). Analysis of volume changes of two isogenic yeast strains of significantly different replicative lifespan during consecutive cell cycles demonstrated that both strains stop budding when reaching the same final volume (Zadrag et al 2005(Zadrag et al , 2006).…”

Section: Introductionmentioning

confidence: 90%

“…We demonstrated that inhibition of budding but not of protein synthesis and cell volume growth by pheromone treatment decreases yeast replicative lifespan in a manner inversely related to the volume attained (Zadrag et al 2005). Analysis of volume changes of two isogenic yeast strains of significantly different replicative lifespan during consecutive cell cycles demonstrated that both strains stop budding when reaching the same final volume (Zadrag et al 2005(Zadrag et al , 2006). An obvious criticism to these results was that they are limited to one pair of strains and they should be confirmed on further cases of different origin.…”

Section: Introductionmentioning

confidence: 90%

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Cell volume as a factor limiting the replicative lifespan of the yeast Saccharomyces cerevisiae

et al. 2008

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The number of cell divisions of the yeast Saccharomyces cerevisiae is limited, referred to as "replicative lifespan" of this organism and believed to be due to aging mechanisms similar to those of mammalian cells. We demonstrate, using three pairs of isogenic yeast strains (standard and a mutant deficient in an antioxidant defense protein) that although the lifespan differs significantly, the final volume attained after the last division is similar within each pair of strains. In a population, cells cease to bud after various number of cell cycles but attaining a similar final volume. These results indicate that the increase in the mother cell volume, intrinsic to the asymmetric cell division in S. cerevisiae, may be the main mechanism limiting the reproductive capacity of in this organism.

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Section: Introductionsupporting

confidence: 90%

Section: Resultsmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 90%

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Cell volume as a factor limiting the replicative lifespan of the yeast Saccharomyces cerevisiae

et al. 2008

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“…(3) The yeast cells increase their volume during each cell cycle (Hartwell & Unger, 1977;Woldringh et al, 1993;Zadrag et al, 2005;Zadrag-Tecza et al, 2009).…”

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confidence: 99%

Hypertrophy hypothesis as an alternative explanation of the phenomenon of replicative aging of yeast

2011

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This paper summarizes numerous arguments demonstrating that the hypothesis of accumulation of the senescence factor, which was the basis for introducing yeast to the group of model organisms of gerontology, finds no experimental support. Among several candidates for the role of the causative agents of replicative aging, only one - hypertrophy - always accompanies symptoms of aging, not only in Saccharomyces cerevisiae, but also in Schizosaccharomyces pombe.

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Current awareness on yeast

2006

Yeast

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In order to keep subscribers up‐to‐date with the latest developments in their field, this current awareness service is provided by John Wiley & Sons and contains newly‐published material on yeasts. Each bibliography is divided into 10 sections. 1 Books, Reviews & Symposia; 2 General; 3 Biochemistry; 4 Biotechnology; 5 Cell Biology; 6 Gene Expression; 7 Genetics; 8 Physiology; 9 Medical Mycology; 10 Recombinant DNA Technology. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted. (4 weeks journals ‐ search completed 19th. Oct. 2004)

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Replicative aging of the yeast does not require DNA replication

Cited by 15 publications

References 17 publications

Cell volume as a factor limiting the replicative lifespan of the yeast Saccharomyces cerevisiae

Cell volume as a factor limiting the replicative lifespan of the yeast Saccharomyces cerevisiae

Hypertrophy hypothesis as an alternative explanation of the phenomenon of replicative aging of yeast

Current awareness on yeast

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