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Neumann, R

doi:10.1111/j.1365-2133.1987.tb05830.x

Cited by 3 publications

(1 citation statement)

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“…Blood glucose levels were slightly decreased in experimental diabetes of the rat32. There are no conclusive data demonstrating the effect on these levels of a single dose of nicotinamide in human Type I34 and Type II diabetes40, 58, 67. Meta‐analysis disclosed that nicotinamide therapy does not alter blood glucose concentrations in recent‐onset human Type I diabetes but may delay deterioration of the residual capacity of β ‐cells68.…”

Section: Effects Of Exogenous Nicotinic Acid and Nicotinamide On Pyrimentioning

confidence: 99%

Pyridine nucleotides in glucose metabolism and diabetes: a review

Wahlberg

Adamson

Svensson

2000

Diabetes Metab. Res. Rev.

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Nicotinamide adenine dinucleotide (NAD) and its derivatives NADH, NADP and NADPH have regulatory functions in the generation of triose phosphates and pyruvate from glucose. In many studies of the influence of the diabetic state on relationships between pyridine nucleotide and glucose metabolism, the focus has been on the sorbitol pathway. Less attention has been paid to other aspects of the role of pyridine nucleotides in pyruvate formation from glucose, in particular the effects of the NAD precursors nicotinamide and nicotinic acid on glucose metabolism. This paper reviews current knowledge of the involvement of pyridine nucleotides and their precursors in glucose catabolism in the normal and diabetic state. Reference is also made to the following three current hypotheses for mechanisms underlying diabetic microangiopathy: Chronic glucose overutilization, caused by hyperglycemia, in tissues which lack insulin receptors and therefore are freely permeable to glucose. Enhancement of sorbitol pathway activity with an ensuing decrease in the ratio of NAD/NADH. Enhanced utilization of both glucose and pyridine nucleotides in formation of triose phosphates and pyruvate. Therapy with NAD precursors like nicotinamide might have corrective effects on these proposed biochemical aberrations, thereby retarding progression of microangiopathy. Copyright © 2000 John Wiley & Sons, Ltd.

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Section: Effects Of Exogenous Nicotinic Acid and Nicotinamide On Pyrimentioning

confidence: 99%

Pyridine nucleotides in glucose metabolism and diabetes: a review

Wahlberg

Adamson

Svensson

2000

Diabetes Metab. Res. Rev.

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Wertewandel

Schütte¹

1996

Das Schöne Fremde

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High dose nicotinamide in the treatment of necrobiosis lipoidica

1988

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An open study of high dose nicotinamide in the treatment of 15 patients with necrobiosis lipoidica is reported. Of 13 patients who remained on treatment for more than 1 month, eight improved. Improvement took the form of a decrease in pain and soreness, a decrease in erythema and the healing of ulcers if present, although the skin did not return completely to normal in any patient. There were no significant side-effects, particularly with respect to diabetic control, an important finding as lesions tended to relapse if treatment was stopped.

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Cited by 3 publications

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Pyridine nucleotides in glucose metabolism and diabetes: a review

Pyridine nucleotides in glucose metabolism and diabetes: a review

Wertewandel

High dose nicotinamide in the treatment of necrobiosis lipoidica

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