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Applying the CAMP trial asthma remission prediction model to the Dutch asthma remission studies

“…Recent studies have provided strong evidence that an opportunity window occurs during the first year of life within which to induce immunologic tolerance. 7 The inverse association between very preterm birth and food allergy identified in our cohort is consistent with both the ''hygiene'' 5 and the ''dual-allergen exposure'' 7 hypotheses, suggesting that earlier exposure to pathogens and early ingestion of food proteins, respectively, might lead to clinical immune tolerance to food allergens in very preterm born infants. Future research should not only aim to identify perinatal exposures that predispose to food allergy but also immunologic mechanisms and early-life environmental factors that might protect from atopic disease and potentially promote a tolerogenic response.…”

“…The definition for airway obstruction is not expected to be the cause, because the difference between FEV 1 /FVC% and FEV 1 /IVC% is marginal in children and young adults with mild to moderate asthma. 7 Taking this into account, we show that the model proposed by Wang et al can correctly predict future development of asthma remission in up to 40% of cases. Although usable, more research is needed to disentangle the pathophysiology of asthma remission, which is a highly relevant yet poorly understood outcome of childhood asthma.…”

Preterm birth reduces the risk of IgE sensitization up to early adulthood: A population‐based birth cohort study

“…Variations during this period might be involved in the pathogenesis of atopy. 13 Our results are consistent with previous research, 9,10,12,17,22,29 however, some studies contradict our conclusions or show no association. 15,21,30,31 Our study makes a significant addition to the literature due to its longitudinal design including repeated measurements of outcome throughout childhood up to early adulthood.…”

“…21 A UK study reported a link between high birth weight or high GA and parent-reported hay fever, 15 while a New Zealand study indicated no association between GA and atopy. 20 Recently, a large populationbased register Swedish study of over 1 million children suggested that very preterm birth (<32 gestational weeks) is associated with lower risk of food allergy, 12 while risk estimates decrease by earlier preterm GA. 22 While evidence suggests that differences in the length of pregnancy shape the pathways of immunologic tolerance, 9,10,12,14,18,20,21 we still have limited reports of IgE sensitization by GA. Previous studies have had various limitations, including inadequate power or the use of self-or parent-reported diagnoses of allergic disease.…”

“…A UK study reported a link between high birth weight or high GA and parent‐reported hay fever, 15 while a New Zealand study indicated no association between GA and atopy 20 . Recently, a large population‐based register Swedish study of over 1 million children suggested that very preterm birth (<32 gestational weeks) is associated with lower risk of food allergy, 12 while risk estimates decrease by earlier preterm GA 22 …”