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Cattaneo, Giorgio; Schumacher, M.; Trummer, Christian; Urbach, Horst; Meckel, Stephan

doi:10.3174/ajnr.a4780

Cited by 1 publication

(1 citation statement)

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“…A temperature of <30°C, corresponding to severe brain hypothermia, was achieved within 30 min with a significant reduction of infarct volumes in a swine MCA occlusion model. [9] Despite this excellent performance, crucial limitations are expected in the frame of a AIS treatment, since extracorporeal circuits require larger catheter dimensions (outer diameter, 14 F) and additional time for the set-up [10] (cit, letter to the editor). Moreover, they demand high heparin doses which can be deleterious in case of postreperfusion hemorrhage.…”

Section: Extracorporeal Coolingmentioning

confidence: 99%

Review of selective brain hypothermia in acute ischemic stroke therapy using an intracarotid, closed-loop cooling catheter

Cattaneo

Meckel

2019

Brain Circ

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In acute ischemic stroke patients, selective brain hypothermia is a promising concept aiming at a fast decrease of brain temperature and thus neuroprotection in the acute phase of ischemia. At the same time, the emergence of mechanical thrombectomy (MT) as an effective treatment in large-vessel occlusion opens the door for a combination of neuroprotective approaches in the frame of a neurovascular, catheter-based intervention. In this regard, intracarotid cooling is a very effective energetic approach, using the blood supply to the penumbra as a fast transport vector for heat exchange in affected brain regions. We review the state of development of a novel closed-loop cooling catheter, describing design-related as well as procedural aspects and presenting results from different theoretical and experimental studies. Finally, we compare the concept with two alternative methods: cold saline infusion and extracorporeal blood cooling. We focus on the combination with MT, considering the effect of different and variable perfusion rates on the final goal of a "cold reperfusion" at the time of blood flow restoration.

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Section: Extracorporeal Coolingmentioning

confidence: 99%