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Banan, Babak; Lin, Yiing; Chapman, William C.

doi:10.1002/lt.24597

Cited by 1 publication

(1 citation statement)

References 14 publications

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“…Different strategies have been investigated in preclinical and pretransplant models (animals and discarded human livers, respectively), including gene silencing, gene transfection, immunomodulation, and even graft defatting in the case of steatotic livers. 98 Although ex situ NMP holds considerable promise, there is ongoing need to establish optimal device conditions and perfusate composition to maintain organ viability for extended periods of days to even weeks, depending on the therapy or intragraft process(es) being targeted. Normothermic liver and kidney perfusates that have applied in clinical transplantation to date are outlined in the next 2 sections and in Tables 3 and 4, and common basic components of both are reflected in Figure 2.…”

Section: Normothermic Mpmentioning

confidence: 99%

Abdominal Organ Preservation Solutions in the Age of Machine Perfusion

et al. 2022

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The past decade has been the foreground for a radical revolution in the field of preservation in abdominal organ transplantation. Perfusion has increasingly replaced static cold storage as the preferred and even gold standard preservation method for marginal-quality organs. Perfusion is dynamic and offers several advantages in comparison with static cold storage. These include the ability to provide a continuous supply of new metabolic substrates, clear metabolic waste products, and perform some degree of organ viability assessment before actual transplantation in the recipient. At the same time, the ongoing importance of static cold storage cannot be overlooked, in particular when it comes to logistical and technical convenience and cost, not to mention the fact that it continues to work well for the majority of transplant allografts. The present review article provides an overview of the fundamental concepts of organ preservation, providing a brief history of static cold preservation and description of the principles behind and basic components of cold preservation solutions. An evaluation of current evidence supporting the use of different preservation solutions in abdominal organ transplantation is provided. As well, the range of solutions used for machine perfusion of abdominal organs is described, as are variations in their compositions related to changing metabolic needs paralleling the raising of the temperature of the perfusate from hypothermic to normothermic range. Finally, appraisal of new preservation solutions that are on the horizon is provided.

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Section: Normothermic Mpmentioning

confidence: 99%