Reply: ‘Second Generation Antipsychotic Drugs: Is There a Common Mechanism in the Development of Obesity?’

Pimozide, a Novel Fatty Acid Binding Protein 4 Inhibitor, Promotes Adipogenesis of 3T3-L1 Cells by Activating PPARγ

“…8,9 Other studies showed that antipsychotic drugs directly induced white adipose tissue, and then disturbed the energy homeo-stasis in the body. 10 The induction of lipid accumulation within fully differentiated adipocytes increases adipocyte size, therefore resulting in increased adipose tissue mass associated with weight gain. 11 For example, weight gain is also the major adverse effect of olanzapine.…”

“…Animal studies showed that olanzapine exhibited direct effects on mature rat adipocytes, increasing adipogenesis and decreasing adipolysis to induce lipid accumulation. 10,12 Further mechanistic study showed that the induction of adipogenesis by olanzapine in 3T3-L1 differentiation models was mediated through the regulation of sterol regulatory element binding protein-1 (SREBP-1). 13 However, the mechanistic details of pimozide-induced weight gain are still unknown.…”