Reply: The peripheral governor does have the final say in limiting muscular performance<sup>1</sup>This paper is a reply to the discussion by de Paula Caraça Smirmaul and Dantas, published in this issue.

MacIntoshBrian, R; S., ShahiM. Reza

doi:10.1139/h11-084

Cited by 1 publication

(1 citation statement)

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“…A heatmap of the differentially expressed statuses of melatonergic genes between cancerous and normal samples is shown in Figure 1A and Supplementary Tables S5, S6. The majority of nuclear receptor genes, intracellular genes, and metabolic genes were underexpressed to varying degrees across cancer types, which is consistent with previous studies (43)(44)(45). Strikingly, CALM1 was significantly underexpressed in all cancer types except for PAAD, whereas CYP1A2 was underexpressed in eight cancer types (e.g., BRCA and LIHC).…”

Section: Overview Of Melatonergic Gene Expression In Cancer Developmentsupporting

confidence: 90%

Integrative Pan-Cancer Analysis Reveals Decreased Melatonergic Gene Expression in Carcinogenesis and RORA as a Prognostic Marker for Hepatocellular Carcinoma

et al. 2021

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BackgroundMelatonin has been shown to play a protective role in the development and progression of cancer. However, the relationship between alterations in the melatonergic microenvironment and cancer development has remained unclear.MethodsWe performed a comprehensive investigation on 12 melatonergic genes and their relevance to cancer occurrence, progression and survival by integrating multi-omics data from microarray analysis and RNA sequencing across 11 cancer types. Specifically, the 12 melatonergic genes that we investigated, which reflect the melatonergic microenvironment, included three membrane receptor genes, three nuclear receptor genes, two intracellular receptor genes, one synthetic gene, and three metabolic genes.ResultsWidely coherent underexpression of nuclear receptor genes, intracellular receptor genes, and metabolic genes was observed in cancerous samples from multiple cancer types compared to that in normal samples. Furthermore, genomic and/or epigenetic alterations partially contributed to these abnormal expression patterns in cancerous samples. Moreover, the majority of melatonergic genes had significant prognostic effects in predicting overall survival. Nevertheless, few corresponding alterations in expression were observed during cancer progression, and alterations in expression patterns varied greatly across cancer types. However, the association of melatonergic genes with one specific cancer type, hepatocellular carcinoma, identified RORA as a tumor suppressor and a prognostic marker for patients with hepatocellular carcinoma.ConclusionsOverall, our study revealed decreased melatonergic gene expression in various cancers, which may help to better elucidate the relationship between melatonin and cancer development. Taken together, our findings highlight the potential prognostic significance of melatonergic genes in various cancers.

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Section: Overview Of Melatonergic Gene Expression In Cancer Developmentsupporting

confidence: 90%

Integrative Pan-Cancer Analysis Reveals Decreased Melatonergic Gene Expression in Carcinogenesis and RORA as a Prognostic Marker for Hepatocellular Carcinoma

et al. 2021

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Reply: The peripheral governor does have the final say in limiting muscular performance¹This paper is a reply to the discussion by de Paula Caraça Smirmaul and Dantas, published in this issue.

Cited by 1 publication

References 10 publications

Integrative Pan-Cancer Analysis Reveals Decreased Melatonergic Gene Expression in Carcinogenesis and RORA as a Prognostic Marker for Hepatocellular Carcinoma

Integrative Pan-Cancer Analysis Reveals Decreased Melatonergic Gene Expression in Carcinogenesis and RORA as a Prognostic Marker for Hepatocellular Carcinoma

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Reply: The peripheral governor does have the final say in limiting muscular performance1This paper is a reply to the discussion by de Paula Caraça Smirmaul and Dantas, published in this issue.

Cited by 1 publication

References 10 publications

Integrative Pan-Cancer Analysis Reveals Decreased Melatonergic Gene Expression in Carcinogenesis and RORA as a Prognostic Marker for Hepatocellular Carcinoma

Integrative Pan-Cancer Analysis Reveals Decreased Melatonergic Gene Expression in Carcinogenesis and RORA as a Prognostic Marker for Hepatocellular Carcinoma

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Reply: The peripheral governor does have the final say in limiting muscular performance¹This paper is a reply to the discussion by de Paula Caraça Smirmaul and Dantas, published in this issue.