Reply to “Antibiotics, intestinal dysbiosis and risk of celiac disease” by Hakim Rahmoune et al. [Digestive and Liver Disease]

Simre, Kärt; Uibo, Oivi; Tillmann, Vallo; Knip, Mikael; Uibo, Raivo

doi:10.1016/j.dld.2016.10.009

Cited by 1 publication

(1 citation statement)

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“…Various cohort and case–controls studies have demonstrated an association between enterovirus and CeD 12–14 although not all studies have demonstrated the association. 28 Furthermore, parechoviruses which are closely related to enterovirus have in stool samples also been associated with later development of CeD in high-risk children. 29 In this study, we did not found an association between diarrhoea and CeD in adolescents, however we dealt with small numbers (less than five).…”

Section: Discussionmentioning

confidence: 99%

Early environmental risk factors and coeliac disease in adolescents: a population-based cohort study in Denmark

Crawley,

Sander,

Nohr

et al. 2023

BMJ Open

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ObjectivesOur aim was to investigate the association between early environmental factors and the development of coeliac disease (CeD) in adolescents, recruited from a cohort nested in the Danish National Birth Cohort (DNBC).DesignThe study was designed as a prospective cohort study, nested in DNBCParticipantsThe Glutenfunen cohort comprises 1266 participants, nested in DNBC. All participants were screened for CeD, and in total, 28 cases of biopsy proven CeD were identified. Data about breastfeeding, timing of introduction to solid food in infancy, use of antibiotics, infections and symptoms were parentally reported prospectively at 6 months and 18 months, respectively. We estimated ORs and 95% CIs of CeD in adolescents using logistic regression analysis.ResultsViral croup reported at 18 months of age was associated with CeD in adolescents with an OR of 3.2 (95% CI: 1.2 to 8.7). Furthermore, otitis media also reported at 18 months of age was linked with CeD with an OR of 3.2 (95% CI: 1.5 to 7.3). We were not able to find any statistical associations between CeD and breastfeeding, frequency of infections, parentally reported use of antibiotic and timing of solid foods.ConclusionIn this study, we present an overview of the relationship between early environmental factors and occurrence of CeD in adolescents. Our findings, despite limitations due to a limited number of cases of CeD, suggest a role of viral infections in the pathogenesis of CeD

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Section: Discussionmentioning

confidence: 99%