Reply to Colorectal cancer and COVID‐19: Do we need to raise awareness and vigilance?

Wu, Qiuji; Zhang, Hongyan; Ye, Zhong; Chua, Melvin L.K.; Xie, Conghua

doi:10.1002/cncr.33218

Cited by 2 publications

(1 citation statement)

References 12 publications

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“…SARS-CoV-2 replication is aided by their support, culminating in GI barrier disruption [11,[91][92][93], and possibly in CRC. Although the influence of the gut microbiota on COVID-19 risk in CRC patients remains poorly understood, the possible mechanisms targeting microbial dysbiosis should be further investigated [94].…”

Section: Gi Microbiota Dysbiosis Associated With Sars-cov-2 Infection...mentioning

confidence: 99%

Gastrointestinal Microbiota Dysbiosis Associated with SARS-CoV-2 Infection in Colorectal Cancer: The Implication of Probiotics

Odun-Ayo

Reddy

2022

Gastroenterology Insights

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The complexity of coronavirus disease 2019 (COVID-19)’s pathophysiology is such that microbial dysbiosis in the lung and gastrointestinal (GI) microbiota may be involved in its pathogenic process. GI microbiota dysbiosis has been associated with respiratory disorders, including COVID-19, as well as sporadic colorectal cancer (CRC) through imbalanced microbiota and compromised immune response. It is pertinent to understand the possible role of probiotics in stabilizing the microbial environment and maintaining the integrity of the respiratory and GI tracts in SARS-CoV-2 induced dysbiosis and colorectal carcinogenesis. The long-term implication of SARS-CoV-2 in GI dysbiosis via microbiota-gut-lung cross-talk could increase the risk of new CRC diagnosis or worsen the condition of previously diagnosed individuals. Recent knowledge shows that the immune-modulatory response to probiotics is shifting the beneficial use of probiotics towards the treatment of various diseases. In this review, we highlight the potential impact of probiotics on SARS-CoV-2 infection associated with CRC through microbiota imbalance in COVID-19 patients.

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