Reply to comment on ‘C.‐P. Tung, N.‐M. Hong, C.‐H. Chen, and Y.‐C. Tan. 2004. Regional daily baseflow prediction. Hydrological Processes 18: 2147–2164’

Abstract

The recession analysis introduced by Brutsaert and Nieber (1977) has been applied in many studies. Tung et al. (2004) stated that using time-averaged flows to estimate coefficients for recession equations may result in bias. The reasons include improper time interval to estimate averaged flows and the coefficient a in the recession analysis depends on the initial water table. The latter implies that the coefficient a may be different for different recession events. Rupp and Woods (2008) commented that the bias can be made negligible by using time intervals that are appropriate to the time rate of change in discharge. However, the bias of estimating coefficient a can still be expected if flows from different recession events are used on a log-log plot. It desires attention even if appropriate time interval is considered.

Association between 23 drugs and Parkinson's disease: A two‐sample Mendelian randomization study

“…Aspirin inhibits the enzyme activity of cyclooxygenase (COX), which affects the generation of prostaglandins (PGs), thereby inhibiting inflammation (Bindu et al, 2020). At the same time, aspirin also has an antioxidative stress effect, which can prevent oxidative damage (Chen et al, 2020;Paseban et al, 2019). Therefore, aspirin may affect PD by influencing these two factors.…”

“…TXA2 (Majithia & Bhatt, 2019). Aspirin also exhibits anti-inflammatory (Bindu et al, 2020) and antioxidant effects (Chen et al, 2020;Paseban et al, 2019) and has been suggested to be beneficial for PD in some studies (Gabbert et al, 2022;Rangasamy et al, 2019;San Luciano et al, 2020). Cilostazol can increase the expression of Nurr1 in mice, protecting the integrity of dopaminergic neurons and reducing inflammation by suppressing NF-κB and its downstream effectors TNF-α and IL-1β (Hedya et al, 2018).…”

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“…151,152 Importantly, many of these procedures are single-step reactions with high yields and will also determine whether the resulting structure is self-supported or must act as a supported membrane. 152,153 Although the variety of available preparative techniques yields exceptional customization capabilities in flux capacity and surface functionality, the synthesis parameters are most commonly obtained experimentally. The result is a time-consuming and laborious optimization path, which has so far been the major roadblock to greater MIP advocacy and application.…”

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