Reply to “Comment on ‘Gold Nanoshells Improve Single Nanoparticle Molecular Sensors'”

Raschke, G.; Brogl, S.; Susha, Andrei S.; Rogach, Andrey L.; Klar, Thomas A.; Feldmann, Jochen; Fieres, B.; Petkov, Nikolay; Bein, Thomas; Nichtl, Alfons; Kürzinger, Konrad

doi:10.1021/nl050130b

Cited by 12 publications

(14 citation statements)

References 12 publications

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“…This assignement is confirmed by the spectral displacement of the former band during nanoshell growth, while, in contrast, the spectral position of the latter remains almost unchanged as expected for small nanospheres [1]. This is further corroborated by TEM measurements showing the presence of large nanoparticles (mean radius R 2 in the 14 nm range) that have been identified as nanoshells, and of smaller ones (mean size of about 4 nm) identified as pure gold [1,14]. The nanoshell SPR energy is determined by the ratio of the inner to outer radius R 1 /R 2 ; the latter was thus estimated by fitting the experimental spectrum with A(ω) = P p A p (ω) + P s A s (ω), where P p and P s are the volume fractions of nanoparticles and nanoshells, respectively, and A p,s (ω) are the corresponding absorbances [1].…”

supporting

confidence: 69%

Coherent Acoustic Vibration of Metal Nanoshells

Guillon¹,

Langot²,

Fatti³

et al. 2006

Nano Lett.

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Using time-resolved pump-probe spectroscopy, we have performed the first investigation of the vibrational modes of gold nanoshells. The fundamental isotropic mode launched by a femtosecond pump pulse manifests itself in a pronounced time-domain modulation of the differential transmission probed at the frequency of nanoshell surface plasmon resonance. The modulation amplitude is significantly stronger, and the period is longer than that in a gold nanoparticle of the same overall size, in agreement with theoretical calculations. This distinct acoustical signature of nanoshells provides a new and efficient method for identifying these versatile nanostructures and for studying their mechanical and structural properties.

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confidence: 69%

Coherent Acoustic Vibration of Metal Nanoshells

Guillon¹,

Langot²,

Fatti³

et al. 2006

Nano Lett.

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“…After synthesis, extensive washing is required to remove contaminating gold colloid from the product. There is some controversy over the exact structure of these particles,39–41 with some groups describing the nanoparticle as a gold sulfide core coated with a thin gold outer shell, while other groups describe these nanoparticles as aggregates of gold with a thin layer of sulfur on the particle surface. Regardless, these gold nanoparticles have an NIR absorbance that can be utilized for ablative therapy.…”

Section: Gold Nanoparticle Design For Photothermal Therapy Applicamentioning

confidence: 99%

A New Era for Cancer Treatment: Gold‐Nanoparticle‐Mediated Thermal Therapies

Kennedy

Bickford

Lewinski

et al. 2010

Small

812

618

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Nanotechnology-based cancer treatment approaches potentially provide localized, targeted therapies that aim to enhance efficacy, reduce side effects, and improve patient quality of life. Gold-nanoparticle-mediated hyperthermia shows particular promise in animal studies, and early clinical testing is currently underway. In this article, the rapidly evolving field of gold nanoparticle thermal therapy is reviewed, highlighting recent literature and describing current challenges to clinical translation of the technology.

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“…26 Zhang and colleagues then proposed a gold nanoparticle aggregate structure. 27 Due to consequent debate about their composition, [28][29][30] specific structural details must be further elucidated. Despite this, potential applications of these nanoparticles reported in the literature continue to grow.…”

Section: Introductionmentioning

confidence: 99%

Antibody-conjugated gold-gold sulfide nanoparticles as multifunctional agents for imaging and therapy of breast cancer

Day¹

2010

IJN

129

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The goal of this study was to develop near-infrared (NIR) resonant gold-gold sulfide nanoparticles (GGS-NPs) as dual contrast and therapeutic agents for cancer management via multiphoton microscopy followed by higher intensity photoablation. We demonstrate that GGS-NPs exposed to a pulsed, NIR laser exhibit two-photon induced photoluminescence that can be utilized to visualize cancerous cells in vitro. When conjugated with anti-HER2 antibodies, these nanoparticles specifically bind SK-BR-3 breast carcinoma cells that over-express the HER2 receptor, enabling the cells to be imaged via multiphoton microscopy with an incident laser power of 1 mW. Higher excitation power (50 mW) could be employed to induce thermal damage to the cancerous cells, producing extensive membrane blebbing within seconds leading to cell death. GGS-NPs are ideal multifunctional agents for cancer management because they offer the ability to pinpoint precise treatment sites and perform subsequent thermal ablation in a single setting.

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Reply to “Comment on ‘Gold Nanoshells Improve Single Nanoparticle Molecular Sensors'”

Cited by 12 publications

References 12 publications

Coherent Acoustic Vibration of Metal Nanoshells

Coherent Acoustic Vibration of Metal Nanoshells

A New Era for Cancer Treatment: Gold‐Nanoparticle‐Mediated Thermal Therapies

Antibody-conjugated gold-gold sulfide nanoparticles as multifunctional agents for imaging and therapy of breast cancer

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