Reply to “does chronic hepatitis E virus infection exist in immunocompetent patients?”

Grewal, Priya

doi:10.1002/hep.27423

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2020

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“…Of particular interest is the first recognition of persistent HEV infection with no underlying immunocompromise. Other published reports to date describing immunocompetent patients with persistent HEV infection have invariably had some level of occult immunosuppression from underlying medical disorders 26‐29 . Therefore, it is important for specialists caring for immunosuppressed patients outwith transplantation, and even patients ostensibly not immunosuppressed, to be aware of the possibility of persistent HEV infection in patients with chronic hepatitis.…”

Section: Discussionmentioning

confidence: 99%

Persistent Hepatitis E virus infection across England and Wales 2009‐2017: Demography, virology and outcomes

Ankcorn

Said

Morgan

et al. 2020

Journal of Viral Hepatitis

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The first clinical case of persistent HEV infection in England was reported in 2009. We describe the demography, virology and outcomes of patients identified with persistent HEV infection in England and Wales between 2009 and 2017. A series of 94 patients with persistent HEV infection, defined by HEV viraemia of more than 12 weeks, was identified through routine reference laboratory testing. Virology, serology and clinical data were recorded through an approved PHE Enhanced Surveillance System. Sixty-six | 421 ANKCORN et Al.

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Section: Discussionmentioning

confidence: 99%