Reply to Dr Yuet al

Cardiovascular Effects of Canagliflozin in Relation to Renal Function and Albuminuria

“…The trial protocols were reviewed by relevant regulatory authorities and ethics committees responsible at each trial site, and all participants provided written informed consent. The design and main results of the CANVAS Program [12][13][14] and the CREDENCE trial 6,7 have been previously published. Within these eGFR groups, 1,352 (70%), 1,380 (46%), and 1,901 (20%) participants, respectively, had baseline UACR >300 mg/g.…”