Reply to FBXW7, L1CAM, and TGM2 in endometrial cancer

Urick, Mary Ellen; Yu, Eui-Young; Bell, Daphne W.

doi:10.1002/cncr.33781

Cited by 2 publications

(1 citation statement)

References 6 publications

(4 reference statements)

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“…This suggests that, when compared to L1CAM, TGM2 might not be of as much value as a druggable target [138]. Further studies involving FBXW7, L1CAM, and TGM2 in ECs are needed [139,140]. Tumor tissues; cell lines Downregulated N.A.…”

Section: Fbxw7 In Endometrial Cancermentioning

confidence: 99%

The Role of FBXW7 in Gynecologic Malignancies

Fiore

Suleiman

Drago-Ferrante

et al. 2023

Cells

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The F-Box and WD Repeat Domain Containing 7 (FBXW7) protein has been shown to regulate cellular growth and act as a tumor suppressor. This protein, also known as FBW7, hCDC4, SEL10 or hAGO, is encoded by the gene FBXW7. It is a crucial component of the Skp1-Cullin1-F-box (SCF) complex, which is a ubiquitin ligase. This complex aids in the degradation of many oncoproteins, such as cyclin E, c-JUN, c-MYC, NOTCH, and MCL1, via the ubiquitin-proteasome system (UPS). The FBXW7 gene is commonly mutated or deleted in numerous types of cancer, including gynecologic cancers (GCs). Such FBXW7 mutations are linked to a poor prognosis due to increased treatment resistance. Hence, detection of the FBXW7 mutation may possibly be an appropriate diagnostic and prognostic biomarker that plays a central role in determining suitable individualized management. Recent studies also suggest that, under specific circumstances, FBXW7 may act as an oncogene. There is mounting evidence indicating that the aberrant expression of FBXW7 is involved in the development of GCs. The aim of this review is to give an update on the role of FBXW7 as a potential biomarker and also as a therapeutic target for novel treatments, particularly in the management of GCs.

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Section: Fbxw7 In Endometrial Cancermentioning

confidence: 99%

The Role of FBXW7 in Gynecologic Malignancies

Fiore

Suleiman

Drago-Ferrante

et al. 2023

Cells

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Prognostic Role of the Removed Vaginal Cuff and Its Correlation with L1CAM in Low-Risk Endometrial Adenocarcinoma

Vizza¹,

Bruno²,

Cutillo³

et al. 2021

Cancers

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Objective: The aim of our study was to investigate the role of the excised vaginal cuff length as a prognostic factor in terms of DFS and recurrence rate/site, in low-risk endometrial cancer (EC) patients. Moreover, we correlated the recurrence with the expression of L1CAM. Material and Methods: From March 2001 to November 2016, a retrospective data collection was conducted of women undergoing surgical treatment for low-risk EC according to ESMO-ESGO-ESTRO consensus guidelines. Patients were divided into three groups according to their vaginal cuff length: V0 without vaginal cuff, V1 with a vaginal cuff shorter than 1.5 cm and V2 with a vaginal cuff longer than or equal to 1.5 cm. Results: 344 patients were included in the study: 100 in the V0 group, 179 in the V1 group and 65 in the V2 group. The total recurrence rate was 6.1%: the number of patients with recurrence was 8 (8%), 10 (5.6%) and 3 (4.6%), in the V0, V1 and V2 group, respectively. No statistically significant difference was found in the recurrence rate among the three groups. Although the DFS was higher in the V2 group, the result was not significant. L1CAM was positive in 71.4% of recurrences and in 82% of the distant recurrences. Conclusions: The rate of recurrence in patients with EC at low risk of recurrence does not decrease as the length of the vaginal cuff removed increases. Furthermore, the size of the removed vaginal cuff does not affect either the site of recurrence or the likelihood of survival.

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Reply to FBXW7, L1CAM, and TGM2 in endometrial cancer

Cited by 2 publications

References 6 publications

The Role of FBXW7 in Gynecologic Malignancies

The Role of FBXW7 in Gynecologic Malignancies

Prognostic Role of the Removed Vaginal Cuff and Its Correlation with L1CAM in Low-Risk Endometrial Adenocarcinoma

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