Reply to JS White

Kavanagh, Kylie; Wylie, Ashley T.; Tucker, Kelly L.; Hamp, Timothy J.; Gharaibeh, Raad Z.; Fodor, Anthony A.; Cullen, John M.

doi:10.3945/ajcn.113.072264

Cited by 2 publications

(3 citation statements)

References 7 publications

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“…Results of several animal studies further suggest that chronic elevated fructose intake may lead to the development of NAFLD and that this at least in part results from impairments of intestinal barrier function and an increased translocation of bacterial endotoxin 25a,29. Similar relations have also been reported for fructose‐induced vascular endothelial dysfunction in rodent models .…”

Section: Discussionsupporting

confidence: 53%

Short‐Term Isocaloric Intake of a Fructose‐ but not Glucose‐Rich Diet Affects Bacterial Endotoxin Concentrations and Markers of Metabolic Health in Normal Weight Healthy Subjects

Nier

Brandt

Rajcic

et al. 2019

Molecular Nutrition Food Res

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Scope Dietary pattern and impairments of intestinal barrier function are discussed to be critical in the development of metabolic impairments. Here, it is determined if an isocaloric exchange of complex carbohydrates with monosaccharides affects markers of intestinal permeability and metabolic health in healthy subjects. Methods and Results After a dietary standardization for 4 days, all 12 subjects aged 21–33 years receive an isocaloric fructose‐ and glucose‐enriched diet for 3 days separated by a wash‐out phase. Anthropometry, blood pressure, markers of intestinal permeability and metabolic as well as inflammatory parameters are determined in blood samples or isolated peripheral blood mononuclear cells collected at baseline, after standardizations and the monosaccharide interventions, respectively. While anthropometric and inflammatory parameters are not changed, the intake of an isocaloric fructose‐ but not glucose‐enriched diet is associated with a significant increase of bacterial endotoxin plasma levels and alanine aminotransferase activity in serum, while total plasma nitrate/nitrite concentrations are significantly decreased. In peripheral blood mononuclear cells, Toll like receptors 4, 2 , and MYD88 mRNA expressions are significantly induced after the fructose‐rich but not the glucose‐rich diet. Conclusion In metabolically healthy subjects, even a short‐term intake of a fructose‐rich diet can elevate bacterial endotoxin levels and change markers of liver health and vascular endothelial function.

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Section: Discussionsupporting

confidence: 53%

Short‐Term Isocaloric Intake of a Fructose‐ but not Glucose‐Rich Diet Affects Bacterial Endotoxin Concentrations and Markers of Metabolic Health in Normal Weight Healthy Subjects

Nier

Brandt

Rajcic

et al. 2019

Molecular Nutrition Food Res

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“…It is widely recognized that high-level fructose consumption contributes to insulin resistance and oxidative stress, as well as hepatic steatosis, which is an early stage in the NAFLD. 7 It is well documented that giving 10-30% fructose solution to mice can induce insulin resistance, oxidative stress, and hepatic steatosis. 2,24,25 Herein, the results of the present study showed that high-fructose feeding in mice for 8 weeks led to significant insulin resistance, hepatic steatosis and oxidative stress observed by hyperglycemia and hyperinsulinemia, as well as the increases in hepatic NEFA and MDA, and the decreases in hepatic T-SOD and GSH-Px activities.…”

Section: Discussionmentioning

confidence: 99%

“…6 Hepatic steatosis is also known to be the accumulation of ectopic fat in the liver and is an early stage in the nonalcoholic fatty liver disease (NAFLD). 7 For this reason, concern has arisen from the realization that fructose, at elevated concentrations, can promote metabolic changes. Despite intense research, current therapeutic options are still limited, and thus the HF-induced insulin resistance and hepatic oxidative stress mouse is an appropriate animal model for evaluating the possible prophylactic or therapeutic effects of natural antioxidants on the insulin resistance population.…”

Section: Introductionmentioning

confidence: 99%

Selenium-containing polysaccharides from Ziyang green tea ameliorate high-fructose diet induced insulin resistance and hepatic oxidative stress in mice

Ren

Luo

et al. 2015

Food Funct.

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The present study was designed to evaluate the effects of selenium-containing tea polysaccharides (Se-GTP) from a new variety of selenium-enriched Ziyang green tea against high fructose (HF)-induced insulin resistance and hepatic oxidative stress in mice. Healthy male Kunming mice were fed 20% high fructose water and administered 200, 400 and 800 mg per kg bw Se-GTP for 8 weeks. Mice fed HF in drinking water displayed significant insulin resistance, hepatic steatosis and oxidative stress observed by hyperglycemia and hyperinsulinemia, as well as increases in hepatic non-esterified fatty acid (NEFA) and malonaldehyde (MDA). The administration of Se-GTP at 400 and 800 mg per kg bw significantly improved insulin sensitivity, and reduced liver steatosis and oxidative stress damage, and brought back the antioxidants and hepatic lipids towards near-normal values. In the oral glucose tolerance test, the administration of Se-GTP at 400 and 800 mg per kg bw had reduced plasma glucose concentrations after 30 min of glucose loading in HF-fed mice, suggesting that Se-GTP improved glucose intolerance. Histopathological examination indicated that the impaired pancreatic/hepatic tissues were effectively restored in HF-fed mice following the Se-GTP treatment. This is the first report showing that Se-GTP can ameliorate the high fructose-induced insulin resistance and hepatic oxidative injury.

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Reply to JS White

Cited by 2 publications

References 7 publications

Short‐Term Isocaloric Intake of a Fructose‐ but not Glucose‐Rich Diet Affects Bacterial Endotoxin Concentrations and Markers of Metabolic Health in Normal Weight Healthy Subjects

Short‐Term Isocaloric Intake of a Fructose‐ but not Glucose‐Rich Diet Affects Bacterial Endotoxin Concentrations and Markers of Metabolic Health in Normal Weight Healthy Subjects

Selenium-containing polysaccharides from Ziyang green tea ameliorate high-fructose diet induced insulin resistance and hepatic oxidative stress in mice

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