Reply to: “Juvenile gangrenous vasculitis of the scrotum – a diagnosis not to forget”

Juvenile gangrenous vasculitis of the scrotum: systematic review

“…Signs of vasculitis including a fibrinoid necrosis of small blood vessel walls with numerous extravasated red cells were detected in seven patients 5,7,8,12–14 . No signs of vasculitis were detected in two patients 3 . Histopathological assessment confirmed the formation of an abscess and patches of suppuration in one patient 16 .…”

“…9 A total of 64.7% (n = 11) of patients had concomitant or a recent history of upper respiratory tract symptoms. 3,5,7,8,[10][11][12][13]15,16,18 Most of the patients (88.2%, n = 15) had a fever ranging between 38°C and 39.6°C.…”

“…Skin biopsies revealed an epidermal necrosis, dense dermal perivascular inflammatory infiltrate with a neutrophilic predominance with or without invading the epidermis (100% of histopathological results, n = 14). 3,5,7,8,[11][12][13][14][15][16] Signs of vasculitis including a fibrinoid necrosis of small blood vessel walls with numerous extravasated red cells were detected in seven patients. 5,7,8,[12][13][14] No signs of vasculitis were detected in two patients.…”

“…Juvenile gangrenous vasculitis of the scrotum (JGVS) is a rare, painful, scrotal ulcer of unknown etiology 1 . Despite being reported in 1974 by Pinol et al., the disease was modestly expanded in recent years with less than 20 cases published in the literature 2,3 . Owing to its rarity and the under‐ or misdiagnosis, the prevalence of the disease is still confusing.…”

“…1 Despite being reported in 1974 by Pinol et al, the disease was modestly expanded in recent years with less than 20 cases published in the literature. 2,3 Owing to its rarity and the under-or misdiagnosis, the prevalence of the disease is still confusing. This emphasizes the need for a greater level of awareness of JGVS diagnosis.…”