Reply to letter on What biological markers could be used for diagnosis and monitoring of nitrous oxide abuse

Abstract

The authors proposed some suggestions about the different biological biomarkers in nitrous oxide (N 2 O) intoxication by highlighting the relevance of homocysteine and methylmalonic acid (MMA) over serum vitamin B12 measurement.The primary objective of our study was to help clinicians to rapidly discriminate between N 2 O-induced neuropathy (N 2 On) and its main differential diagnosis, namely, Guillain-Barré syndrome [2], by characterizing the most efficient clinical, biological, and electrolateral sclerosis,