Reply to Sharifpour et al.: Light response measurement of the human SCN by 7T fMRI

Meijer, Johanna H.; Rover, Mischa de; Gutiérrez, Pablo de Torres; Swaab, Dick F.; Osch, Matthias J.P. van; Schoonderwoerd, Robin A.

doi:10.1073/pnas.2215410119

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A Boundary Mapping Technique Was Employed To Allow Localizat...1

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2023

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“…Although the estimated size is still smaller than our 2 mm cubic voxel, the elongated shape of the SCN can be more appropriately covered by a larger ROI, presumably by our 2 mm cubic voxel. Moreover, owing to the 2 mm voxel size larger than the SCN 39 , the location of the SCN voxel was largely appropriate in individual structural images (Supplementary Fig. 2b).…”

Section: A Boundary Mapping Technique Was Employed To Allow Localizat...mentioning

confidence: 99%

Diurnal variation of brain activity in the human suprachiasmatic nucleus

Oka

Ogawa

Osada

et al. 2023

Preprint

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The suprachiasmatic nucleus (SCN) is the central clock for circadian rhythms. Animal studies have revealed daily rhythms in the neuronal activity in the SCN. However, the circadian activity of the human SCN has remained elusive. In this study, to reveal the diurnal variation of the SCN activity in humans, the SCN was localized, and its activity was investigated using perfusion imaging. We scanned each participant four times a day, every six hours, and higher activity was observed at noon while lower activity was recorded in the early morning. The SCN activity was then measured every thirty minutes for six hours from midnight to dawn and showed a decreasing trend and was comparable with the rodent SCN activity after switching off the lights. These results suggest that the diurnal variation of the human SCN follows the zeitgeber cycles of mammals and is modulated by physical lights rather than the local time.

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Section: A Boundary Mapping Technique Was Employed To Allow Localizat...mentioning

confidence: 99%