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Flöistrup, H.; SWARTZ, J; BERGSTROM, A; Alm, Johan; Scheynius, A.; VANHAGE, M; Waser, Marco; Braun‐Fahrländer, Charlotte; Schram-Bijkerk, Dieneke; Huber, Machteid

doi:10.1016/j.jaci.2006.02.024

Cited by 3 publications

(3 citation statements)

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“…This relationship was not modified by the inclusion of atopic sensitization in the final analysis. This is consistent with two other studies where there was no association between the use of antibiotics in the first year of life and the development of allergic sensitization even though antibiotic use was associated with the development of asthma [23,24].…”

Section: Discussionsupporting

confidence: 92%

Risk factors for asthma at 3.5 and 7 years of age

Mitchell¹,

Robinson²,

Black³

et al. 2007

Clin Experimental Allergy

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There was a significant association between antibiotic use and day care in the first year of life and wheezing at 7 y but not at 3.5 y. This strengthens the argument that these factors increase the risk of asthma. We have also made the novel observation that sleeping on a used mattress in the first year of life is a risk factor for wheezing at 3.5 and 7 y. Capsule summary This prospective study of 871 children made the novel observation that sleeping on a used mattress in the first year of life was a risk factor for wheezing at 3.5 and 7 y.

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Section: Discussionsupporting

confidence: 92%

Risk factors for asthma at 3.5 and 7 years of age

Mitchell¹,

Robinson²,

Black³

et al. 2007

Clin Experimental Allergy

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“…Several studies have demonstrated an association between antibiotic exposure during infancy and an increased risk of asthma development [10][11][12][13][14][15][16][17][18][19][20][21]. We previously reported a dosedependent relationship between increasing number of infant antibiotic courses and development of childhood asthma [22].…”

mentioning

confidence: 99%

Dose, Timing, and Type of Infant Antibiotic Use and the Risk of Childhood Asthma

Donovan

Abreo

et al. 2019

Clinical Infectious Diseases

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Background Aspects of infant antibiotic exposure and its association with asthma development have been variably explored. We aimed to evaluate comprehensively and simultaneously the impact of dose, timing, and type of infant antibiotic use on the risk of childhood asthma. Methods Singleton, term-birth, non–low-birth-weight, and otherwise healthy children enrolled in the Tennessee Medicaid Program were included. Infant antibiotic use and childhood asthma diagnosis were ascertained from prescription fills and healthcare encounter claims. We examined the association using multivariable logistic regression models. Results Among 152 622 children, 79% had at least 1 antibiotic prescription fill during infancy. Infant antibiotic use was associated with increased odds of childhood asthma in a dose-dependent manner, with a 20% increase in odds (adjusted odds ratio [aOR], 1.20 [95% confidence interval {CI}, 1.19–1.20]) for each additional antibiotic prescription filled. This significant dose-dependent relationship persisted after additionally controlling for timing and type of the antibiotics. Infants who had broad-spectrum-only antibiotic fills had increased odds of developing asthma compared with infants who had narrow-spectrum-only fills (aOR, 1.10 [95% CI, 1.05–1.19]). There was no significant association between timing, formulation, anaerobic coverage, and class of antibiotics and childhood asthma. Conclusions We found a consistent dose-dependent association between antibiotic prescription fills during infancy and subsequent development of childhood asthma. Our study adds important insights into specific aspects of infant antibiotic exposure. Clinical decision making regarding antibiotic stewardship and prevention of adverse effects should be critically assessed prior to use during infancy.

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“…T ype I allergy is an IgE-mediated hypersensitivity disease that affects .25% of the population worldwide (1). The simultaneous binding of IgE Abs to at least two different epitopes on allergens is a prerequisite for the cross-linking of mast cell and basophil-bound IgE Abs by allergens (2,3).…”

mentioning

confidence: 99%

Mapping of Conformational IgE Epitopes with Peptide-Specific Monoclonal Antibodies Reveals Simultaneous Binding of Different IgE Antibodies to a Surface Patch on the Major Birch Pollen Allergen, Bet v 1

Gieras

Cejka

Blatt

et al. 2011

The Journal of Immunology

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Allergic inflammation is based on the cross-linking of mast cell and basophil-bound IgE Abs and requires at least two binding sites for IgE on allergens, which are difficult to characterize because they are often conformational in nature. We studied the IgE recognition of birch pollen allergen Bet v 1, a major allergen for >100 million allergic patients. Monoclonal and polyclonal Abs raised against Bet v 1-derived peptides were used to compete with allergic patients’ IgE binding to Bet v 1 to search for sequences involved in IgE recognition. Strong inhibitions of patients’ IgE binding to Bet v 1 (52–75%) were obtained with mAbs specific for two peptides comprising aa 29–58 (P2) and aa 73–103 (P6) of Bet v 1. As determined by surface plasmon resonance, mAb2 specific for P2 and mAb12 specific for P6 showed high affinity, but only polyclonal rabbit anti-P2 and anti-P6 Abs or a combination of mAbs inhibited allergen-induced basophil degranulation. Thus, P2 and P6 define a surface patch on the Bet v 1 allergen, which allows simultaneous binding of several different IgE Abs required for efficient basophil and mast cell activation. This finding explains the high allergenic activity of the Bet v 1 allergen. The approach of using peptide-specific Abs for the mapping of conformational IgE epitopes on allergens may be generally applicable. It may allow discriminating highly allergenic from less allergenic allergen molecules and facilitate the rational design of active and passive allergen-specific immunotherapy strategies.

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Cited by 3 publications

References 1 publication

Risk factors for asthma at 3.5 and 7 years of age

Risk factors for asthma at 3.5 and 7 years of age

Dose, Timing, and Type of Infant Antibiotic Use and the Risk of Childhood Asthma

Mapping of Conformational IgE Epitopes with Peptide-Specific Monoclonal Antibodies Reveals Simultaneous Binding of Different IgE Antibodies to a Surface Patch on the Major Birch Pollen Allergen, Bet v 1

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