Repopulation of the Spleen of X-Irradiated Rabbits by Tritium-Labeled Lymphoid Cells of the Shielded Appendix

Production of an Antibody Deficiency Syndrome in Rabbits by Neonatal Removal of Organized Intestinal Lymphoid Tissues

“…Süssdorf, studying rabbits and using pulse labeling with tritiated thymidine, presented evidence confirming that the shielded appendix in the irradiated animal indeed seeds lymphoid cells to the spleen and mesenteric lymph node (71). The more recent studies of M iller (55) confirmed in essence the findings of J acobson et al and Sussdorf and contributed that shielding of the thymus fostered re development of still a separate population of small lympoid cells.…”

Immune Response in Irradiated Mice with Peyer's Patch Shielding.

“…These studies were conducted using dosages of irradiation in the LDso range, thus permitting the bone marrow of survivors to regenerate, though not as rapidly as the lymphatic tissues (5). Recently Sussdorf (6) has repeated our original study and found an essentially similar course of events.…”

In Vitro Studies on Radiation Lymphoid Recovery of Mouse Spleen

“…In view of the similarity between experimental results on lymphopoiesis in neonatal and adult-irradiated mice subjected to thymectomy, one might wonder whether the lymphoid regeneration process operates by the same mechanism as embryonic lymphoid development. In this context, the question was raised whether lymphoid cell migration and repopulation (18,19) play an essential role in regeneration.…”