Report and review of the fetal brain disruption sequence

Corona‐Rivera, Jorge Román; Corona-Rivera, E.; Romero‐Velarde, Enrique; Hernández-Rocha, Juan; Bobadilla‐Morales, Lucina; Corona‐Rivera, Alfredo

doi:10.1007/s004310100813

Cited by 53 publications

(46 citation statements)

References 9 publications

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“…Clinically defined with presumed extrinsic (non-genetic) cause Foetal brain disruption sequence (Corona-Rivera et al ., 2001) Clinically defined with AR inheritanceFamilial foetal brain disruption-like syndrome with unknown causeFamilial ‘microhydranencephaly’ with unknown cause (Behunova et al ., 2010) Genetically defined with AR inheritanceFamilial ‘microhydranencephaly’ associated with mutations of MHAC at 16p13.13–p12.2 (Kavaslar et al ., 2000)…”

Section: Appendixmentioning

confidence: 99%

A developmental and genetic classification for malformations of cortical development: update 2012

Barkovich

Guerrini

Kuzniecky

et al. 2012

Brain

906

831

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Malformations of cerebral cortical development include a wide range of developmental disorders that are common causes of neurodevelopmental delay and epilepsy. In addition, study of these disorders contributes greatly to the understanding of normal brain development and its perturbations. The rapid recent evolution of molecular biology, genetics and imaging has resulted in an explosive increase in our knowledge of cerebral cortex development and in the number and types of malformations of cortical development that have been reported. These advances continue to modify our perception of these malformations. This review addresses recent changes in our perception of these disorders and proposes a modified classification based upon updates in our knowledge of cerebral cortical development.

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Section: Appendixmentioning

confidence: 99%

A developmental and genetic classification for malformations of cortical development: update 2012

Barkovich

Guerrini

Kuzniecky

et al. 2012

Brain

906

831

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“…Findings of microcephaly, cortical and subcortical atrophy, and redundant scalp skin in some infants are suggestive of fetal brain disruption sequence, in which disruption of fetal brain growth leads to skull collapse. 36 Other findings included talipes and arthrogryposis, likely to be secondary to neurologic involvement. Ophthalmologic abnormalities (including chorioretinal atrophy, optic nerve hypoplasia and pallor, and lens subluxation) have been described in infants born with microcephaly who are suspected of having congenital Zika virus infection.…”

Section: Fetalmentioning

confidence: 99%

Zika Virus Disease: A CDC Update for Pediatric Health Care Providers

et al. 2016

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Zika virus is a mosquito-borne flavivirus discovered in Africa in 1947. Most persons with Zika virus infection are asymptomatic; symptoms when present are generally mild and include fever, maculopapular rash, arthralgia, and conjunctivitis. Since early 2015, Zika virus has spread rapidly through the Americas, with local transmission identified in 31 countries and territories as of February 29, 2016, including several US territories. All age groups are susceptible to Zika virus infection, including children. Maternal–fetal transmission of Zika virus has been documented; evidence suggests that congenital Zika virus infection is associated with microcephaly and other adverse pregnancy and infant outcomes. Perinatal transmission has been reported in 2 cases; 1 was asymptomatic, and the other had thrombocytopenia and a rash. Based on limited information, Zika virus infection in children is mild, similar to that in adults. The long-term sequelae of congenital, perinatal, and pediatric Zika virus infection are largely unknown. No vaccine to prevent Zika virus infection is available, and treatment is supportive. The primary means of preventing Zika virus infection is prevention of mosquito bites in areas with local Zika virus transmission. Given the possibility of limited local transmission of Zika virus in the continental United States and frequent travel from affected countries to the United States, US pediatric health care providers need to be familiar with Zika virus infection. This article reviews the Zika virus, its epidemiologic characteristics, clinical presentation, laboratory testing, treatment, and prevention to assist providers in the evaluation and management of children with possible Zika virus infection.

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“…34,35 It is an expression of an underlying disturbance of the growth of the brain and, when severe, can be associated with several, significant neurologic problems, including seizures, cerebral palsy, developmental delay and intellectual disabilities. 36,37 Microcephaly is the consequence of a process of fetal brain disruption sequence, 14,38 leading to the destruction of fetal brain tissue with diminished intracranial pressure, followed by the collapse of the fetal skulls. 34 Microcephaly can be determined by multiple different conditions, 35 including genetic and infectious causes (congenital infection by rubella, cytomegalovirus, toxoplasmosis, herpes virus, HIV) as well as exposure to alcohol, drugs or other environmental toxic substances.…”

Section: Microcephaly and Cns Abnormalitiesmentioning

confidence: 99%

Zika virus infection and pregnancy: what we do and do not know

Ticconi

Pietropolli

Rezza

2016

Pathogens and Global Health

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Recent data strongly suggest an association between the current outbreak of ZIKA virus (ZIKV) in many countries of Central and South America and a sharp increase in the detection of microcephaly and fetal malformations. The link with brain defect, which has been detected mainly in some areas of Brazil, is supported by the following evidence: (1) ZIKV transmission from infected pregnant women to their fetuses; (2) the potential of ZIKV to determine a specific congenital fetal syndrome characterized by abnormalities involving primarily the developing brain and eye. In particular, the risk of transmission and congenital disease appears to be restricted to mother's infection during the first trimester of pregnancy. Among brain defects, microcephaly, brain calcifications, and ventriculomegaly are the most frequent abnormalities of the central nervous system detected so far. However, relevant information on effect of maternal infection with ZIKV on the fetus is still limited. In this review, we focus our attention on current knowledge about ZIKV infection in pregnancy, discussing relevant issues and open problems which merit further investigation.

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Report and review of the fetal brain disruption sequence

Cited by 53 publications

References 9 publications

A developmental and genetic classification for malformations of cortical development: update 2012

A developmental and genetic classification for malformations of cortical development: update 2012

Zika Virus Disease: A CDC Update for Pediatric Health Care Providers

Zika virus infection and pregnancy: what we do and do not know

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