Report of a fatal case of Lassa fever in Parakou in 2018: clinical, therapeutic and diagnostic aspects

Attinsounon, Cossi Angelo; Ibara, Bienvenu Rolland Ossibi; Alassani, Adébayo; Adè, S.; Saké, Khadidjatou; Kakaï, Clément Glèlè; Dovonou, Albert

doi:10.1186/s12879-018-3587-6

Cited by 8 publications

(4 citation statements)

References 14 publications

(11 reference statements)

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“…If confirmed, such a native-to-invasive turn over in rodent species would have important consequences in terms of public health. For instance, M. natalensis is the main reservoir of the Lassa virus, which is responsible for annual epidemics of Lassa hemorragic fevers in West Africa (review in Monath [100]), including Benin [101]. To date, the virus has never been identified in Rattus spp., thus likely precluding widespread circulation of the zoonotic agents in Southern Benin cities where R. rattus have largely replaced M. natalensis.…”

Section: Species Diversity and Co-occurrence Patternsmentioning

confidence: 99%

Native and Invasive Small Mammals in Urban Habitats along the Commercial Axis Connecting Benin and Niger, West Africa

et al. 2019

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Based on compiled small mammal trapping data collected over 12 years from Benin and Niger (3701 individual records from 66 sampling sites), located in mainland Africa, we here describe the small mammal community assemblage in urban habitats along the commercial axis connecting the two countries, from the seaport of Cotonou to the Sahelian hinterland, with a particular focus on invasive species. In doing so, we document extant species distributions, which highlight the risks of continuing the range expansion of three synanthropic invasive rodent species, namely black rats (Rattus rattus), brown rats (R. norvegicus), and house mice (Mus musculus). Using various diversity estimates and community ecology approaches, we detect a latitudinal gradient of species richness that significantly decreased Northward. We show that shrews (Crocidura) represent a very important component of micro-mammal fauna in West African towns and villages, especially at lower latitudes. We also demonstrate that invasive and native synanthropic rodents do not distribute randomly in West Africa, which suggests that invasive species dynamics and history differ markedly, and that they involve gradual, as well as human-mediated, long distance dispersal. Patterns of segregation are also observed between native Mastomys natalensis and invasive rats R. rattus and R. norvegicus, suggesting potential native-to-invasive species turn over. Consequences of such processes, especially in terms of public health, are discussed.

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Section: Species Diversity and Co-occurrence Patternsmentioning

confidence: 99%

Native and Invasive Small Mammals in Urban Habitats along the Commercial Axis Connecting Benin and Niger, West Africa

et al. 2019

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“…For example, outbreak of severe acute respiratory syndrome (SARS) in 2002/ 2003, caused by SARS coronavirus (SARS-CoV) transmitted from wildlife animal reservoirs, was associated with 774 deaths in 8096 infected individuals [4]. Ebola virus (EBOV) and Lassa virus (LASV) that cause Ebola disease and Lassa fever diseases, which are characterized with severe haemorrhagic fever, multi-organ failure, and high mortality rate, are currently circulating in West Africa and remain to be big challenges to medical community [5,6].…”

Section: Introductionmentioning

confidence: 99%

GILT restricts the cellular entry mediated by the envelope glycoproteins of SARS-CoV, Ebola virus and Lassa fever virus

Chen

Hou

Jiang

et al. 2019

Emerging Microbes & Infections

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Interferons (IFNs) control viral infections by inducing expression of IFN-stimulated genes (ISGs) that restrict distinct steps of viral replication. We report herein that gamma-interferon-inducible lysosomal thiol reductase (GILT), a lysosome-associated ISG, restricts the infectious entry of selected enveloped RNA viruses. Specifically, we demonstrated that GILT was constitutively expressed in lung epithelial cells and fibroblasts and its expression could be further induced by type II interferon. While overexpression of GILT inhibited the entry mediated by envelope glycoproteins of SARS coronavirus (SARS-CoV), Ebola virus (EBOV) and Lassa fever virus (LASV), depletion of GILT enhanced the entry mediated by these viral envelope glycoproteins. Furthermore, mutations that impaired the thiol reductase activity or disrupted the N-linked glycosylation, a posttranslational modification essential for its lysosomal localization, largely compromised GILT restriction of viral entry. We also found that the induction of GILT expression reduced the level and activity of cathepsin L, which is required for the entry of these RNA viruses in lysosomes. Our data indicate that GILT is a novel antiviral ISG that specifically inhibits the entry of selected enveloped RNA viruses in lysosomes via disruption of cathepsin L metabolism and function and may play a role in immune control and pathogenesis of these viruses.

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“…The epidemics of 2014 and 2016 occurred in the rainy season (April to October) and dry season (November to March), indicating that there is no preferential season. However, the new cases that appeared in 2017, 2018, and 2019 suggest an upsurge in the dry season [25,26,31]. The question arises as to why people are more infected in the dry season.…”

Section: Discussionmentioning

confidence: 99%

Lassa fever in Benin: description of the 2014 and 2016 epidemics and genetic characterization of a new Lassa virus

Yadouléton¹,

Picard

Rieger

et al. 2020

Emerging Microbes & Infections

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We report two outbreaks of Lassa fever that occurred in Benin in 2014 and 2016 with 20 confirmed cases and 50% (10/20) mortality. Benin was not previously considered to be an endemic country for Lassa fever, resulting in a delay to diagnose the disease and its human transmission. Molecular investigations showed the viral genomes to be similar to that of the Togo strain, which is genetically very different from other known strains and confirms the existence of a new lineage. Endemic circulation of Lassa virus in a new territory and the genetic diversity thus confirm that this virus represents a growing threat for West African people. Given the divergence of the Benin strain from the prototypic Josiah Sierra Leone strain frequently used to generate vaccine candidates, the efficacy of vaccine candidates should also be demonstrated with this strain.

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Report of a fatal case of Lassa fever in Parakou in 2018: clinical, therapeutic and diagnostic aspects

Cited by 8 publications

References 14 publications

Native and Invasive Small Mammals in Urban Habitats along the Commercial Axis Connecting Benin and Niger, West Africa

Native and Invasive Small Mammals in Urban Habitats along the Commercial Axis Connecting Benin and Niger, West Africa

GILT restricts the cellular entry mediated by the envelope glycoproteins of SARS-CoV, Ebola virus and Lassa fever virus

Lassa fever in Benin: description of the 2014 and 2016 epidemics and genetic characterization of a new Lassa virus

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