Report of a symposium on diagnosis and treatment of adult soft tissue sarcomas in the head and neck

Balm, Alfons J. M.; Coevorden, Frits van; Bos, Kurt E.; Fletcher, C. D. M.; Gortzak, E.; Gregor, R. T.; Hilgers, Frans J. M.; Keus, Ronald B.; Koops, Willem; Kroon, Bin B. R.; Laan, Bernard F.A.M. van der; Loftus, B. M.; Nieweg, OE; Somers, R.; Wanebo, W.J.

doi:10.1016/s0748-7983(95)91558-3

Cited by 30 publications

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“…26 Nevertheless, it is difficult to achieve en bloc tumor resection in patients who have sarcomas that infiltrate the anterior skull base. Although tumor resection should be the objective of surgery, our series, along with other reports, indicates that negative surgical margins are achieved in <50% of patients.…”

Section: Discussionmentioning

confidence: 99%

Analysis of prognostic factors in 146 patients with anterior skull base sarcoma: An international collaborative study

Gil

Patel

Singh

et al. 2007

Cancer

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BACKGROUND. Single‐institutional studies lack sufficient power to assess the role of surgery and radiotherapy in the management of sarcomas involving the anterior skull base. For this study, an international collaborative study group analyzed a large cohort of patients who underwent surgery for the treatment of skull base tumors. METHODS. A subset of 146 patients who had a histologic diagnosis of skull base sarcoma (SBS) formed the basis of this report. Most patients were aged ≥21 years (77%) and had stage IV disease (56%). Adjuvant radiotherapy was received by 35% of patients, and chemotherapy was received by 10% of patients. RESULTS. Orbital involvement was encountered in 53% of patients, involvement of the orbital wall was encountered in 46% of patients, and intracranial extension was encountered in 28% of patients. Positive microscopic margins were reported in 43% of patients (51 of 118 patients). Treatment‐related complications were reported in 27% of patients, and postoperative mortality was reported in 1.4% of patients. With a median follow‐up of 34 months, the 5‐year overall, disease‐specific, and recurrence‐free survival rates were 62%, 64%, and 57%, respectively. Tumor grade and adjuvant radiotherapy were not significant predictors of survival. Prior radiotherapy, intraorbital extension, positive margins, and postoperative complications were significant predictors of reduced disease‐specific survival on univariate analysis. The presence of positive/close margins, however, was the only independent predictor of poor overall, recurrence‐free, and disease‐specific survival on multivariate analysis (relative risk, 2.4; P = .006). The 5‐year disease‐specific survival rate was 77%, 43%, and 36% for patients with negative, close, and positive margins, respectively. CONCLUSIONS. The current results indicated that wide craniofacial resection with negative margins is an independent prognostic predictor of better outcome. Patients with positive margins have a high risk for tumor recurrence independent of tumor grade. Cancer 2007. © 2007 American Cancer Society.

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Section: Discussionmentioning

confidence: 99%

Analysis of prognostic factors in 146 patients with anterior skull base sarcoma: An international collaborative study

Gil

Patel

Singh

et al. 2007

Cancer

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“…In general, sarcomas have a bimodal distribution, being more common in pediatric patients and adults aged 40 to 50 years. 14 Our series contained only a few pediatric cases, because most of the childhood sarcomas are treated with radiotherapy and chemotherapy, and only those with recurrence or incomplete disease regression are referred for a surgical opinion.…”

Section: Discussionmentioning

confidence: 99%

Multidisciplinary management of head and neck sarcomas

et al. 2005

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“…The optimal treatment is complete resection [5,[65][66]. Postoperative adjuvant radiotherapy is indicated for patients with low-grade tumors who have close (< 1cm) or positive margins, as well as those with high-grade tumors [66][67]. Patients with incompletely resectable tumors are treated initially with radiotherapy [50][51]66].…”

Section: Discussionmentioning

confidence: 99%

Diagnosis and Treatment of Head and Neck Sarcomas: Personal Experiences

Laus¹

2013

JCTR

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Sarcomas are a rare group of tumors. They do not commonly manifest as malignancies in the head and neck region. The rare nature of these tumors has resulted in a limited number of publications. This is a descriptive study. We included patients with primary sarcomas of the head and neck, observed between 1991 and 2011 in the department of Otorhinolaryngology (University of Chieti, Italy). We studied the following variables: age, gender, race, origin, primary anatomical location of the neoplasm, pathology, diagnosis and type of cancer treatment employed. During the study period, we found 9 patients with head and neck sarcomas. Of this sample, 6 were males, and 3 were females. The man/woman ratio was 2:1. As far as age is concerned, the most affected age range was between 60 and 80 years. The mean age of the patients was 62. As far as pathology is concerned, we found 7 histopathological variations of sarcomas, and the most common type was the leiomyosarcoma. The most widely used treatment modality was surgical treatment. The data in this study show that head and neck sarcomas are rare tumors with high histological variability, which may involve different anatomical sites. Since these are rare and not well-known lesions, further epidemiological studies must be carried out, in order to give us more knowledge about the disease.

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Report of a symposium on diagnosis and treatment of adult soft tissue sarcomas in the head and neck

Cited by 30 publications

References 0 publications

Analysis of prognostic factors in 146 patients with anterior skull base sarcoma: An international collaborative study

Analysis of prognostic factors in 146 patients with anterior skull base sarcoma: An international collaborative study

Multidisciplinary management of head and neck sarcomas

Diagnosis and Treatment of Head and Neck Sarcomas: Personal Experiences

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