Report of a workshop on the immune response to solid tumours in man

Stevenson, G T; Laurence, D. J. R.

doi:10.1002/ijc.2910160602

Cited by 14 publications

(1 citation statement)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Extensive studies on experimental and human systems have shown the complexity of the tumorassociated host response (Stevenson and Laurence, 1975). It became clear that the results of any in vitro test should be interpreted with caution for its relevance to the clinical picture.…”

mentioning

confidence: 99%

Search for anti‐tumor response in a bone tumor patient with a long clinical history

Vánky

Klein

Cornain

et al. 1976

Intl Journal of Cancer

View full text Add to dashboard Cite

Immunological studies are presented on a patient with a long clinical history suggesting the existence of a tumor-specific immune response. His tumor, first considered benign, progressed to a highly malignant osteosarcoma. Cell-mediated immune reactivity against biopsy cells and against tumor extract was detected in vitro by the autologous tumor stimulation test (ATS) and in vivo by the skin test. In one ATS-test with tumor extract, blastogenesis of T-cells was demonstrated. The amount of Ig(s) in consecutive biopsies increased. Biopsies taken in the later period of the disease stimulated only after trypsin treatment. This stimulation was inhibited by autologous serum or acid eluate of the biopsy. The inhibitory factor in the serum was not intact immunoglobin. Blood lymphocytes did not show a discriminatory or disease-related cytotoxicity, either directly or after co-cultivation with the tumor material. Lymphocytes isolated from one biopsy were non-reactive in both the ATS and the cytotoxicity test.

show abstract

mentioning

confidence: 99%

Search for anti‐tumor response in a bone tumor patient with a long clinical history

Vánky

Klein

Cornain

et al. 1976

Intl Journal of Cancer

View full text Add to dashboard Cite

show abstract

Bronchogenic carcinoma: Survival after surgical treatment according to stage, histologic type and immunomorphologic changes in regional lymph nodes

Tosi

Luzi

Leoncini

et al. 1981

Cancer

View full text Add to dashboard Cite

The survival rates of 90 patients who underwent operation for bronchogenic carcinoma were analyzed statistically according to sex, age, tumor stage and histologic type, types of surgical procedures (lobectomy or pneumonectomy), and to immunomorphologic parameters of immunologic activity in peribronchial and hilar lymph nodes. The Stage I group survived significantly longer than did the Stage II and III groups, the lobectomized patients survived significantly longer than the pneumonectomized patients. The absence or presence of lymph node metastases was one of the major determinants of survival. The mean values (percent of total node cut surface) of lymph node sinus histiocytosis and of paracortical area could be correlated directly to survival in each of the histologic tumor-type groups, while the development of follicular cortex and germinal centers correlated inversely with survival. Increased survival might be associated with changes concomitant with immune reactivity in lymph node T-cell areas and with the sinus histiocytosis pattern, the latter representing probably a tumor--host reaction of the delayed hypersensitivity type. By contrast, increased activity of lymph node B-cell areas tended to correlate with poor prognosis of lung cancer patients. Moreover, patterns showing germinal center hyperplasia were statistically associated with lymph node neoplastic invasion, while the pattern with sinus histiocytosis and expanded paracortical areas was statistically associated with tumor-free lymph nodes.

show abstract

The Cell Periphery and Metastasis

Weiss¹

1980

Brain Metastasis

View full text Add to dashboard Cite

Report of a workshop on the immune response to solid tumours in man

Cited by 14 publications

References 35 publications

Search for anti‐tumor response in a bone tumor patient with a long clinical history

Search for anti‐tumor response in a bone tumor patient with a long clinical history

Bronchogenic carcinoma: Survival after surgical treatment according to stage, histologic type and immunomorphologic changes in regional lymph nodes

The Cell Periphery and Metastasis

Contact Info

Product

Resources

About