“…Among the plant phenolics tested in Supplementary Table 1, targeted assays have discovered DNA gyrase inhibitory activity for 11 phenolic compounds (Ohemeng et al, 1993; Wu et al, 2013b), type III secretion inhibition for 9 compounds (Tsou et al, 2016), inhibition of helicase activity for 5 phenolic compounds (Xu et al, 2001), multi-drug efflux pump inhibitors for 3 compounds (Smith et al, 2007; Fiamegos et al, 2011; Bag and Chattopadhyay, 2014), dehydratase inhibition for 3 compounds (Zhang et al, 2008), protein kinase inhibition for 2 compounds (Shakya et al, 2011), and single phenolic compounds among which one inhibited urease activity (Moon et al, 2013), one bound iron (Chung et al, 1998), one inhibited succinate dehydrogenase and malate dehydrogenase (Yao et al, 2012), one intercalated into DNA (Lou et al, 2012), one induced DNA fragmentation, an ROS response, and suppressed FtsZ expression (Hwang and Lim, 2015), and one bound to the FtsZ protein and inhibited FtsZ assembly (Rai et al, 2008). Many of these results clearly come from large experimental activity screens in which several phenolic compounds were assessed for a single mechanism of action.…”