Report of Combined Therapy in Leprosy with Rifampicin and Isoprodian Conducted at the Bisidimo-Center, Ethiopia

Abstract

On the basis of experimental results by the Borstel Research Institute, 62 patients (BL and LL cases) from the Bisidimo-Center, Ethiopia, received a combination of rifampicin and Isoprodian for a definite length of time under control and clinicai conditions. In the same way 18 patients under dapsone monotherapy could be observed.During treatment good improvement could be seen under both medications, however, the improvement was better under the combined therapy. Side-effects were exceptional; reactions occurred in both grou ps.After therapy had to be discontinued, regular controls of the patients were arranged. In the dapsone group a deterioration was soon found, and treatment had to be continued; After combined therapy, however, the trend of improvement continued, the clinicai and bacteriological improvement has shown to be progres sive ; up to now (in many cases more than 2 years after treatment was stopped) no persistent signs of relapse could be found. The patients will continue under further observation.

New Forms of Multidrug Therapy for the Treatment of Leprosy

“…2), deals with the combinations RMP+SXT (sulfa methoxazole + trimethoprim) + INH and RMP + SXT + PTH. Clinical experience gained in pilot stud ies has already confirmed the therapeutical effect and the tolerance of these combinations [1,6,8,11,24,32,35,36,44,48,49).…”

“…Besides, the synergistic effects of the drugs can be practically exploited. In this way, qualitatively new chemotherapeutical effects can be obtained [9,21,22,25,33,[36][37][38][39][40][45][46][47].…”

Antibiotic X-63 in Experimental Candidiasis of Mice

“…5-Fluorocytosine (Flucytosine, Ancobon), amphotericin B (Fungizone), clotrimazole (Camesten), miconazole nitrate (Micatin, Monistat) and rifampin (Rifadine, Rimactane) have been used in systemic candidiasis [Fa.v.v and Perkins, 1971;Tassel and Madoff, 1968;Premsingh et al, 1976] but there is every justification to increase its therapeutic action by combined drug thera py, increasing use of triple or quadruple drug therapy is found in the fields of cancer tuberculosis and leprosy chemotherapy \Vishwanathan et Rohde, 1975;Bonadonna et al, 1975]. It may well be that 5-fluorocytosine is combined with clotrima zole [bis-phenyl-l-(2-chlorophenyl)-l-imidazolyl methane] and miconazole [l-{-2-(2,4-dichlorphenyl)-2-(2,4 dichloro-phenyl methoxy) ethyl}-lH-imidazole mononitrate] may not be fully effective in Candida endo carditis.…”