Report of Entropion in Newborn Lambs

McManus, T. J.

doi:10.1111/j.1751-0813.1960.tb08577.x

Cited by 8 publications

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Entropion is an eye health problem where the eyelid rolls toward the eye, causing the hair and lashes to contact the eye and can cause blindness [ 1 ]. Blindness can occur because of corneal abrasion or secondary infections, which are common if the condition is not treated [ 2 ]. Several factors may contribute to the development of entropion, including congenital causes [ 3 , 4 ], selective breeding [ 5 , 6 ], scar tissue formation [ 7 , 8 ], and/or age-related processes [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

“…There is evidence of genetic components to the development of entropion in sheep [ 22 ]. Reported worldwide frequency of entropion in lambs is quite variable from 1.1% to 80% [ 1 , 2 , 4 , 23 , 24 ]. There are methods to correct entropion in lambs [ 25 ] but intervention by a veterinarian or trained personnel is costly, and untreated lambs may become blind [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

“…Reported worldwide frequency of entropion in lambs is quite variable from 1.1% to 80% [ 1 , 2 , 4 , 23 , 24 ]. There are methods to correct entropion in lambs [ 25 ] but intervention by a veterinarian or trained personnel is costly, and untreated lambs may become blind [ 2 ]. Approximately 600,000 lambs in the U.S may be afflicted if entropion has a 10% frequency, costing about $150,000 per year to correct assuming a trained technician was paid minimum wage and could process 25 lambs per hour.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Genome-Wide Association Identifies SLC2A9 and NLN Gene Regions as Associated with Entropion in Domestic Sheep

2015

View full text Add to dashboard Cite

Entropion is an inward rolling of the eyelid allowing contact between the eyelashes and cornea that may lead to blindness if not corrected. Although many mammalian species, including humans and dogs, are afflicted by congenital entropion, no specific genes or gene regions related to development of entropion have been reported in any mammalian species to date. Entropion in domestic sheep is known to have a genetic component therefore, we used domestic sheep as a model system to identify genomic regions containing genes associated with entropion. A genome-wide association was conducted with congenital entropion in 998 Columbia, Polypay, and Rambouillet sheep genotyped with 50,000 SNP markers. Prevalence of entropion was 6.01%, with all breeds represented. Logistic regression was performed in PLINK with additive allelic, recessive, dominant, and genotypic inheritance models. Two genome-wide significant (empirical P<0.05) SNP were identified, specifically markers in SLC2A9 (empirical P = 0.007; genotypic model) and near NLN (empirical P = 0.026; dominance model). Six additional genome-wide suggestive SNP (nominal P<1x10-5) were identified including markers in or near PIK3CB (P = 2.22x10-6; additive model), KCNB1 (P = 2.93x10-6; dominance model), ZC3H12C (P = 3.25x10-6; genotypic model), JPH1 (P = 4.68x20-6; genotypic model), and MYO3B (P = 5.74x10-6; recessive model). This is the first report of specific gene regions associated with congenital entropion in any mammalian species, to our knowledge. Further, none of these genes have previously been associated with any eyelid traits. These results represent the first genome-wide analysis of gene regions associated with entropion and provide target regions for the development of sheep genetic markers for marker-assisted selection.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Genome-Wide Association Identifies SLC2A9 and NLN Gene Regions as Associated with Entropion in Domestic Sheep

2015

View full text Add to dashboard Cite

show abstract

“…Entropion is an inversion of the margin of the lower lid or both eyelids, so that the eyelashes rub the cornea. Entropion occurs in a range of species: in puppies (Formston, 1952; Ettinger and Feldman, 2000), kitten (Ettinger and Feldman, 2000), foals (Leader, 1952; Kobluk et al, 1995), calves (Willoughby, 1968), kids (Wyman, 1983; Moore and Whitley, 1984) and in lambs (Litteljohn, 1954; McManus, 1960; Crowely and McGloughlin, 1963; Taylor and Catchpole, 1986; Green et al, 1995; Yeruham and Perl, 2000).…”

Section: Introductionmentioning

confidence: 99%

Entropion, Corneal Ulcer and Corneal Haemorrhages in a One‐Humped Camel (Camelus dromedarius)

Yeruham

Straten

Elad

2002

Journal of Veterinary Medicine, Series B

View full text Add to dashboard Cite

An unusual case of entropion, corneal ulcer and corneal haemorrhages in a one-humped camel (Camelus dromedaries) is described. The most prominent clinical findings were entropion of both eyelids, severe blephrospasm, epiphora, conjunctivitis, conjunctival oedema, mucopurulent conjunctival discharges, hyperaemia, lacrimation and photophobia. Corneal ulcers and corneal haemorrhages were also observed.

show abstract

“…E . , 1950Stringam, 1958Tyler, 1957Weber, 1962Bowen, 1962Barron, 1959Schlotthauer, 1955 Hunter, 1932 E a l e s , 1932Nutting, 1942Hodgman, 1963Startup, 1960 Gibbons, 1963aParish, 1962Archibald, 1962Buonaccorsi, 1960Maki, 1962Moulton, 1961aPritchard, 1964Schofield, 1948Tucker, 1962Alexander, 1959Pritchard, 1964Hodgman, 1963Startup, 1960Crowley, 1963McManus, 1960Atkeson, 1944Barto, 1952Parry, 1959van Rogoert, 1938Eaton, 1937Pullar, 1963Roberts, S.J., 1956 Roberts, S. J., 1956Parish, 1962Roberts, S.J., 1956Brenon, 1958Cronin, 1955Doll, 1952Pritchard, 1964Buxton, 1953Doll, 1954 Wheat, 1960Eaton, 1937Neal, 1964Gibbons, 1963Patterson, 1959Patterson, 1963Plummer, 1949Brinkhaus, 1950 Brown, R.C., 1963 Field, R. A., 1946Graham, 1949…”

mentioning

confidence: 99%