Report of the committee on the genetic constitution of chromosome 3

Naylor, S.L.; Bishop, D. Timothy

doi:10.1159/000132783

Cited by 24 publications

(2 citation statements)

References 7 publications

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“…All probes are available from ATCC. The first three loci have been mapped to 3p25-26 (Naylor and Bishop, 1989), 3p24 , and 3p21 (Naylor and Bishop, 1989), respectively, and D3S32 has been linked to D3F15S2 by pedigree analysis (Naylor and Bishop, 1989). These sequences allowed detection of WLPs when genomic DNA samples were digested with the appropriate restriction enzyme: BgZI for p627, Hind111 for pBH302 and pH3H2, and TaqI for pEFD145.1.…”

Section: Dna Analysismentioning

confidence: 99%

Implication of RARB in Epidermoid (Squamous) Lung Cancer

Houle

Leduc

Bradley

1991

Genes Chromosomes & Cancer

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We report a higher frequency of loss of heterozygosity at loci on the short arm of chromosome 3 in human epidermoid lung tumors than in other non-small cell lung tumors. This observation together with the already known involvement of the retinoids in the development of epidermoid metaplasia and neoplasia, especially in lung tissue, prompted us to investigate by RNAase protection assays the status of expression of a gene that maps on chromosome band 3p24 and codes for the B receptor for retinoic acid (RARB). We show that expression of RARB is detectable in normal lung tissue and in most of the cell lines derived from lung tumors, including the five non-small cell lines that clearly had a non-epidermoid phenotype. Strikingly, however, only one of the five epidermoid-tumor-derived cell lines studied showed detectable expression of RARB. Of two lines derived from adenosquamous tumors, one had a clear epidermoid differentiation, and this line also did not express RARB. Taken together, our results strongly implicate RARB in the evolution of epidermoid lung tumors.

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Section: Dna Analysismentioning

confidence: 99%

Implication of RARB in Epidermoid (Squamous) Lung Cancer

Houle

Leduc

Bradley

1991

Genes Chromosomes & Cancer

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“…This bovine syntenic group, unassigned syntenic group 10 (U10), was later shown to contain SST (6 (2, 7-'9). Additionally, the transferrin gene (TF), which is proximal to SST on HSA 3 (10), was mapped to determine whether U10 included HSA 3q genes not present on MMU 16. TF has been localized to MMU 9 in a conserved syntenic group with aminoacylase (ACYI) (11).…”

mentioning

confidence: 99%

Evidence for the evolutionary origin of human chromosome 21 from comparative gene mapping in the cow and mouse.

Threadgill

Kraus²,

Krawetz³

et al. 1991

Proc. Natl. Acad. Sci. U.S.A.

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To determine the extent of conservation between bovine syntenic group U1O, human chromosome 21 (HSA 21), and mouse chromosome 16 (MMU 16), 11 genes were physically mapped by segregation analysis in a bovine-hamsuter hybrid somatic cell panel. The genes chosen for study span MMU 16 and represent virtually the entire q arm of HSA 21. Because the somatostatin gene (SST), an HSA 3/MMU 16 locus, was previously shown tube in U1O, the trnsferrin gene (TF), an HSA 3/MMU 9 marker, was also mapped to determine whether U10 contains any HSA 3 genes not represented on MMU 16. With the exception of the protamine gene PRMI

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Gene of type II autosomal dominant retinitis pigmentosa maps on the long arm of chromosome 3

et al. 1990

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Linkage analysis has been performed on a large Australian family segregating for the autosomal dominant form of retinitis pigmentosa (ADRP). The majority of patients had no subjective symptoms of night blindness until their second decade and good visual acuity until late in life. The disease in this family has been classified as Type II ADRP according to the subdivisions provided by both Massof and Finkelstein and Fishman and colleagues. Linkage (Omax:0.08 at Zmax:4.78) is here demonstrated between the disease locus and D3S47 (a marker locus on the long arm of chromosome 3), which showed in an earlier study very close linkage without recombination to the disease locus in an Irish pedigree with a clinically more severe and early onset (Type I) ADRP.

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Report of the committee on the genetic constitution of chromosome 3

Cited by 24 publications

References 7 publications

Implication of RARB in Epidermoid (Squamous) Lung Cancer

Implication of RARB in Epidermoid (Squamous) Lung Cancer

Evidence for the evolutionary origin of human chromosome 21 from comparative gene mapping in the cow and mouse.

Gene of type II autosomal dominant retinitis pigmentosa maps on the long arm of chromosome 3

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