Report of two cases with autoerythrocyte sensitization syndrome

Abstract

Auto-erythrocyte Sensitization Syndrome, also known as Gardner Diamond syndrome, is characterized by spontaneous painful and repetitive purpura. Here, we report two women aged 14 and 18 years who were diagnosed with auto-erythrocyte sensitization syndrome by typical laboratory, clinical, histopathological features and intradermal skin test. Burning and itching were the major complaints associated with spontaneous ecchymosis. The frequency of attacks in the patient using a specific serotonin re-uptake inhibitor due to migraine was significantly higher than the patient who did not receive psychiatric treatment. It was concluded that careful psychiatric evaluation is important for effective treatment of the disease.

A review of psychocutaneous disorders from a psychotherapeutic perspective—Toolkit for the dermatologist

“…Patients present with isolated or multiple painful oedematous lesions progressing to bluish ecchymosis with a yellowish hue primarily located on the extremities. Psychotherapy and the placebo effect have produced positive results 23–24 …”

“…Psychotherapy such as CBT is also recommended and is most successful in combination with a SSRI. Other medication classes such as antipsychotics, anxiolytics, and other antidepressants may be used to treat comorbid conditions 24–102 …”

“…Other medication classes such as antipsychotics, anxiolytics, and other antidepressants may be used to treat comorbid conditions. 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 <...…”

“…Psychotherapy and the placebo effect have produced positive results. [23][24] The most common psychiatric comorbidities are depressive disorders, anxiety disorders, illness anxiety disorder, borderline personality disorder (BPD), histrionic personality disorder, bipolar disorder, conversion disorder, and obsessive compulsive disorders. 23,24 SSRIs are the most effective treatment for this condition.…”

“…[23][24] The most common psychiatric comorbidities are depressive disorders, anxiety disorders, illness anxiety disorder, borderline personality disorder (BPD), histrionic personality disorder, bipolar disorder, conversion disorder, and obsessive compulsive disorders. 23,24 SSRIs are the most effective treatment for this condition. Psychotherapy such as CBT is also recommended and is most successful in combination with a SSRI.…”