The study evaluated the association between ultra-processed foods (UPFs) and nutrient intake and identified the sociodemographic characteristics associated with UPF consumption among a nationally representative sample of middle-older adults. Dietary assessment was collected in 2013 using a validated food frequency questionnaire. The Nova system was used to classify food and drinks into UPFs. The percentage of dietary energy from UPFs was calculated and used throughout the analyses, and average nutrient intake across quintiles of UPFs was evaluated. The determinants associated with the dietary caloric contribution of UPF intake were investigated using linear regression models. A cross-sectional analysis of a nationally representative study of Americans over the age of 50, the Health and Retirement Study, was conducted. The analysis included 6,220 participants. The mean age was 65 (SE 0.28) years, with 55% being female. UPF intake accounted for 51% (SE 0.25) of total intake. An increase in the percentage of (%UPF) consumption was correlated with an increase in calories, carbohydrates, saturated fat, and sugar, and a decrease in fiber, vitamins, and minerals. %UPF intake was inversely associated with being Hispanic, higher income, physical activity, vegetarian diet, and Mediterranean diet but positively associated with very low food insecurity. UPFs represented half of the calories consumed. A higher %UPF intake was associated with a lower nutrient profile, suggesting decreasing %UPF intake as a strategy to improve the nutritional quality of middle-older adults. A few sociodemographic factors were associated with %UPFs, which would help in planning strategies to reduce UPF consumption.