Reporter Alleles in hiPSCs: Visual Cues on Development and Disease
Gustavo Caldeira Cotta,
Rachel Castro Teixeira dos Santos,
Guilherme Mattos Jardim Costa
et al.
Abstract:Reporter alleles are essential for advancing research with human induced pluripotent stem cells (hiPSCs), notably in developmental biology and disease modeling. This study investigates the state-of-the-art gene-editing techniques tailored for generating reporter alleles in hiPSCs, emphasizing their effectiveness in investigating cellular dynamics and disease mechanisms. Various methodologies, including the application of CRISPR/Cas9 technology, are discussed for accurately integrating reporter genes into the s… Show more
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