2024
DOI: 10.1101/2024.10.08.617282
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Reporter CRISPR screens deciphercis- andtrans-regulatory principles at theXistlocus

Till Schwämmle,
Gemma Noviello,
Eleni Kanata
et al.

Abstract: Developmental genes are controlled by an ensemble ofcis-acting regulatory elements (REs), which in turn respond to multipletrans-acting transcription factors (TFs). Understanding how acis-regulatory landscape integrates information from many dynamically expressed TFs has remained a challenge. We develop a combined CRISPR-screening approach using endogenous RNA and RE-reporters as readouts. Applied to theXistlocus, crucial for X-chromosome inactivation in females, this method allows us to comprehensively identi… Show more

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