Reporting in rodent models of ‘chemobrain’: a systematic review assessing compliance with the ARRIVE guidelines

George, Reshma; Semendric, Ines; Bowley-Schubert, Eleanor R; Chivonivoni, Christine T; Warrender, Alexandra P; Whittaker, Alexandra L.

doi:10.1007/s00520-021-06312-8

Cited by 8 publications

(8 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The occurrence of ≥ grade 1 confusion was 5% for patients aged under 65 years and 13.6% for patients aged 65 years and over (p = 0.17). Chemotherapy-induced cognitive impairment (chemobrain) could also explain this increased confusion from SRT2, although it was not representative in our series [33].…”

Section: Discussionmentioning

confidence: 67%

Acute Toxicities and Cumulative Dose to the Brain of Repeated Sessions of Stereotactic Radiotherapy (SRT) for Brain Metastases: a Retrospective Study of 184 Patients

Kuntz

Fèvre

Jarnet

et al. 2022

Preprint

View full text Add to dashboard Cite

BackgroundStereotactic radiation therapy (SRT) is a focal treatment for brain metastases (BMs); thus, 20 to 40% of patients will require salvage treatment after an initial SRT session, either because of local or distant failure. SRT is not exempt from acute toxicity, and the acute toxicities of repeated SRT are not well known. The objective of this study was to analyze the acute toxicities of repeated courses of SRT and to determine whether repeated SRT could lead to cumulative brain doses equivalent to those of whole-brain radiotherapy (WBRT).Material and MethodsBetween 2010 and 2020, data from 184 patients treated for 915 BMs via two to six SRT sessions for local or distant BM recurrence without previous or intercurrent WBRT were retrospectively reviewed. Patients were seen via consultations during SRT, and the delivered dose, the use of corticosteroid therapy and neurological symptoms were recorded and rated according to the CTCAEv4. The dosimetric characteristics of 79% of BMs were collected, and summation plans of 76.6% of BMs were created.Results36% of patients developed acute toxicity during at least one session. No grade 3 or 4 toxicity was registered, and grade 1 or 2 cephalalgy was the most frequently reported symptom. There was no significant difference in the occurrence of acute toxicity between consecutive SRT sessions. In the multivariate analysis, acute toxicity was associated with the use of corticosteroid therapy before irradiation (OR=2.6; p=0.01), BMV grade (high vs. low grade OR=5.17; p=0.02), and number of SRT sessions (3 SRT vs. 2 SRT: OR=2.64; p=0.01). The median volume equivalent to the WBRT dose (VWBRT) was 47.9 mL. In the multivariate analysis, the VWBRT was significantly associated with the total GTV (p<0.001) and number of BMs (p<0.001). Even for patients treated for more than 10 cumulated BMs, the median BED to the brain was very low compared to the dose delivered during WBRT.ConclusionRepeated SRT for local or distant recurrent BM is well tolerated, without grade 3 or 4 toxicity, and does not cause more acute neurological toxicity with repeated SRT sessions. Moreover, even for patients treated for more than 10 BMs, the VWBRT is low.

show abstract

Section: Discussionmentioning

confidence: 67%

Acute Toxicities and Cumulative Dose to the Brain of Repeated Sessions of Stereotactic Radiotherapy (SRT) for Brain Metastases: a Retrospective Study of 184 Patients

Kuntz

Fèvre

Jarnet

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…The occurrence of ≥ grade one confusion was 5% for patients aged under 65 years and 13.6% for patients aged 65 years and over (p = 0.17). Chemotherapy-induced cognitive impairment (chemobrain) could also explain this increased confusion from SRT2, although it was not representative in our series [ 38 ]. A prospective study would certainly have allowed us to better distinguish the toxicity related to SRT itself from that of systemic treatments and to better take into account the effect of corticosteroid therapy.…”

Section: Discussionmentioning

confidence: 99%

Acute toxicities and cumulative dose to the brain of repeated sessions of stereotactic radiotherapy (SRT) for brain metastases: a retrospective study of 184 patients

et al. 2023

View full text Add to dashboard Cite

Background Stereotactic radiation therapy (SRT) is a focal treatment for brain metastases (BMs); thus, 20 to 40% of patients will require salvage treatment after an initial SRT session, either because of local or distant failure. SRT is not exempt from acute toxicity, and the acute toxicities of repeated SRT are not well known. The objective of this study was to analyze the acute toxicities of repeated courses of SRT and to determine whether repeated SRT could lead to cumulative brain doses equivalent to those of whole-brain radiotherapy (WBRT). Material and methods Between 2010 and 2020, data from 184 patients treated for 915 BMs via two to six SRT sessions for local or distant BM recurrence without previous or intercurrent WBRT were retrospectively reviewed. Patients were seen via consultations during SRT, and the delivered dose, the use of corticosteroid therapy and neurological symptoms were recorded and rated according to the CTCAEv4. The dosimetric characteristics of 79% of BMs were collected, and summation plans of 76.6% of BMs were created. Results 36% of patients developed acute toxicity during at least one session. No grade three or four toxicity was registered, and grade one or two cephalalgy was the most frequently reported symptom. There was no significant difference in the occurrence of acute toxicity between consecutive SRT sessions. In the multivariate analysis, acute toxicity was associated with the use of corticosteroid therapy before irradiation (OR = 2.6; p = 0.01), BMV grade (high vs. low grade OR = 5.17; p = 0.02), and number of SRT sessions (3 SRT vs. 2 SRT: OR = 2.64; p = 0.01). The median volume equivalent to the WBRT dose (VWBRT) was 47.9 ml. In the multivariate analysis, the VWBRT was significantly associated with the total GTV (p < 0.001) and number of BMs (p < 0.001). Even for patients treated for more than ten cumulated BMs, the median BED to the brain was very low compared to the dose delivered during WBRT. Conclusion Repeated SRT for local or distant recurrent BM is well tolerated, without grade three or four toxicity, and does not cause more acute neurological toxicity with repeated SRT sessions. Moreover, even for patients treated for more than ten BMs, the VWBRT is low.

show abstract

“…Thus this should be considered when interpreting the preclinical results reported in the present systematic review. The observed limitations in animal studies have been identified, highlighted, and reported in multiple systematic reviews ( 229 – 231 ). This has led to journals requiring the use of reporting guidelines, such as the ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines.…”

Section: Discussionmentioning

confidence: 99%

A systematic review of the biological mediators of fat taste and smell

Jaime-Lara

Brooks

Vizioli

et al. 2023

Physiological Reviews

View full text Add to dashboard Cite

Taste and smell play a key role in our ability to perceive foods. Overconsumption of highly palatable energy-dense foods can lead to increased caloric intake and obesity. Thus there is growing interest in the study of the biological mediators of fat taste and associated olfaction as potential targets for pharmacologic and nutritional interventions in the context of obesity and health. The number of studies examining mechanisms underlying fat taste and smell has grown rapidly in the last 5 years. Therefore, the purpose of this systematic review is to summarize emerging evidence examining the biological mechanisms of fat taste and smell. A literature search was conducted of studies published in English between 2014 and 2021 in adult humans and animal models. Database searches were conducted using PubMed, EMBASE, Scopus, and Web of Science for key terms including fat/lipid, taste, and olfaction. Initially, 4,062 articles were identified through database searches, and a total of 84 relevant articles met inclusion and exclusion criteria and are included in this review. Existing literature suggests that there are several proteins integral to fat chemosensation, including cluster of differentiation 36 (CD36) and G protein-coupled receptor 120 (GPR120). This systematic review will discuss these proteins and the signal transduction pathways involved in fat detection. We also review neural circuits, key brain regions, ingestive cues, postingestive signals, and genetic polymorphism that play a role in fat perception and consumption. Finally, we discuss the role of fat taste and smell in the context of eating behavior and obesity.

show abstract

Reporting in rodent models of ‘chemobrain’: a systematic review assessing compliance with the ARRIVE guidelines

Abstract: Reporting in rodent models of 'chemobrain': a systematic review assessing compliance with the ARRIVE guidelines

Cited by 8 publications

References 43 publications

Acute Toxicities and Cumulative Dose to the Brain of Repeated Sessions of Stereotactic Radiotherapy (SRT) for Brain Metastases: a Retrospective Study of 184 Patients

Acute Toxicities and Cumulative Dose to the Brain of Repeated Sessions of Stereotactic Radiotherapy (SRT) for Brain Metastases: a Retrospective Study of 184 Patients

Acute toxicities and cumulative dose to the brain of repeated sessions of stereotactic radiotherapy (SRT) for brain metastases: a retrospective study of 184 patients

A systematic review of the biological mediators of fat taste and smell

Contact Info

Product

Resources

About