Reporting IVF outcomes: The devil is in the detail

ANZJOG turns 60!

“…Our current issue, 60(1), some six decades later, illustrates more of the discoveries and advances made in our specialty during ANZJOG ’s lifetime. There is an excellent editorial from Homer, in conjunction with the paper from Farquhar et al, on the reporting of assisted reproductive technology (ART) success rates in Australia and New Zealand . This nicely complements the fascinating history of the development of ART in the Arthur Wilson Oration given by McBain at the RANZCOG Annual Scientific Meeting in Melbourne in October 2019; a condensed version of the Oration is presented here …”

Epigenetic clock and methylation study of oocytes from a bovine model of reproductive aging

“…Fertility in women begins to decline significantly by their mid‐30 s and pregnancies in women of advanced age lead to higher rates of miscarriage and/or aneuploid offspring (Baired et al, 2005). Despite these risks, women and couples often postpone pregnancy to a more convenient time which has led to a decline in birthrate among most industrialized societies (Homer, 2020; Navot et al, 1991). This decline in fertility can be explained by the age‐related decline in oocyte quality which manifests itself by chromosomal abnormalities, spindle defects, mitochondrial dysfunction, and epigenetic modifications (Baired et al, 2005; Kikuchi et al, 2000; Liu et al, 2002; López‐Otín et al, 2013; Pellestor et al, 2003; Xu et al, 1997).…”

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The mammalian female reproductive axis is the first to fail in aging; however, the molecular mechanisms underpinning this failure are largely unknown, particularly in oocytes (Chamani & Keefe, 2019;Garg & Sinclair, 2015;Homer, 2020). Fertility in women begins to decline significantly by their mid-30 s and pregnancies in women of advanced age lead to higher rates of miscarriage and/or aneuploid offspring (Baired et al, 2005).

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