Reporting thyroid fine-needle aspiration: Literature review and a proposal

Wang, Helen H.

doi:10.1002/dc.20400

Cited by 114 publications

(88 citation statements)

References 81 publications

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“…The system currently and most commonly used contains six categories as follows: benign, lesion (atypia) of undetermined significance, follicular neoplasm, suspicious, malignant, or nondiagnostic. 77,79,[81][82][83] This scheme is summarized in Table 1 Thyroid Aspiration Cytology V. Malignant Specimen is diagnostic of papillary carcinoma, medullary carcinoma, anaplastic carcinoma, or metastatic carcinoma. When using the diagnostic category of malignant, the type of malignancy should be stated whenever possible.…”

Section: Adequate Sampling Of Solid and Cystic Lesionsmentioning

confidence: 99%

Thyroid Aspiration Cytology: Current Status

Layfield¹,

Cibas²,

Gharib³

et al. 2009

CA: A Cancer Journal for Clinicians

156

115

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In the adult population, thyroid nodules are common and are increasingly detected by ultrasound examination or other scanning techniques. Depending on their size and ultrasonographic features, these nodules may require further investigation, including tissue diagnosis. Fine-needle aspiration (FNA) has become the predominant method to obtain tissue for microscopic analysis. In October 2007, the National Cancer Institute sponsored a conference to review the state of the science for the use of FNA in the management of thyroid nodules. This conference reviewed indications for thyroid FNA and pre-FNA requirements, training and credentialing, techniques for thyroid FNA, diagnostic terminology and morphologic criteria, utilization of ancillary studies, and post-FNA testing and treatment options. The results of those discussions have been published in both print and electronic versions. The aim of the current article was to discuss indications for FNA, diagnostic terminology, and post-FNA options, issues that are important to physicians who are managing patients with thyroid nodules. CA Cancer J Clin 2009;59: 99-110.

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Section: Adequate Sampling Of Solid and Cystic Lesionsmentioning

confidence: 99%

Thyroid Aspiration Cytology: Current Status

Layfield¹,

Cibas²,

Gharib³

et al. 2009

CA: A Cancer Journal for Clinicians

156

115

View full text Add to dashboard Cite

show abstract

“…8 However, published data are difficult to compare because there is no uniform agreed-upon terminology in use in the literature, as underlined by Helen Wang in her published review. 19 There is an obvious need for terminology standardization.…”

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confidence: 99%

Liquid‐based FNAC of the thyroid

Geers

Bourgain²

2010

Cancer Cytopathology

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BACKGROUND:The aims of this study were to analyze cytomorphological features of Tripath PREP (BD SurePath, Burlington, NC) preparations in thyroid nodules and to examine adequacy and accuracy of SurePath and frozen sections for both clinical outcome and histological diagnosis when applicable.METHODS:Gathered during a period of 4 years, 712 SurePath specimens of the thyroid were included. Histological (n = 207) or clinical follow‐up (n = 505) was available in all cases. During the same period, 253 frozen sections of surgical thyroid resection specimens were also assessed. Sensitivity, specificity, accuracy, positive predictive value, and negative predictive value were calculated.RESULTS:Sensitivity was 77% for SurePath and 29% for frozen section; specificity was 81% for SurePath and 100% for frozen section; accuracy was 80% for SurePath and 90% for frozen section. One hundred seventy‐eight (25%) SurePath patients were considered unsatisfactory for diagnosis. In this study, sensitivity, specificity, and accuracy were comparable for SurePath and other reported results of liquid‐based thyroid cytology. Presence of free colloid or pure cystic changes favored a benign diagnosis. Cellular smears with nuclear atypia of papillary carcinoma allowed an overt diagnosis of malignancy.CONCLUSIONS:The authors concluded that SurePath is a reliable technique for assessment of thyroid nodules and offers the advantage of easy identification of colloid and atypical nuclei. Supplementary frozen section analysis should be limited to an FNAC diagnosis of suspicious for papillary carcinoma. Cancer (Cancer Cytopathol) 2011. © 2010 American Cancer Society.

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“…The Bethesda subcategory, AUS/FLUS, constitutes an interesting entity, and its ratio is not expected to exceed 7 %; although, in the literature, it may be as high as 27 % [5,10,12]. Our analysis found 4.3 % AUS/FLUS lesions.…”

Section: Discussionmentioning

confidence: 47%

“…It is not a homogeneous category for predicting the risk of malignancy, since the cellular patterns vary; cytological atypia suggestive of papillary carcinoma appears to have a higher risk of malignancy [4]. The risk of malignancy in this category may be as high as 20 % [5,9], contrary to the general knowledge of its potential, and may be disturbing for both the clinician and the patient.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of Fine-Needle Aspiration of Thyroid Nodules in a Series of 1,100 Patients: Correlation Between Cytology and Histopathology Original Article.

et al. 2014

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In this study, our aim was to test the usefulness of The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) in indeterminate lesions in which cytological and histological diagnosis discordance was high and to investigate the contribution of TBSRTC in this indeterminate diagnostic group. The medical records of the patients who presented to the Haydarpasa Numune Training and Research Hospital in Istanbul, Turkey, between October of 1999 and September of 2010, for the cytological and histological diagnosis of thyroid nodules, were reviewed retrospectively. We reclassified these patients according to the Bethesda method, which features well-defined cytological criteria for each category within a six-tiered system. For each patient, the diagnosis and reasons for discordance were discussed and a final decision was made for each discordant case. The overall distribution of the cytological diagnoses using an in-house system was as follows: 811 benign (73.7 %), 87 suspicious follicular cell/follicular neoplasia (7.9 %), 52 suspicious for malignancy (4.7 %), and 45 malignant (4.1 %). We reclassified the diagnoses using the Bethesda system and the results are as follows: 797 benign (73.7 %), 48 follicular lesion of undetermined significance (4.3 %), 68 follicular neoplasia (7.9 %), 40 suspicious for malignancy (3.6 %), and 44 malignant (4 %). Our results showed that using TBRSTC for the lesions in the indeterminate category decreased the ratios of false-positive and falsenegative diagnoses.

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Reporting thyroid fine-needle aspiration: Literature review and a proposal

Cited by 114 publications

References 81 publications

Thyroid Aspiration Cytology: Current Status

Thyroid Aspiration Cytology: Current Status

Liquid‐based FNAC of the thyroid

Evaluation of Fine-Needle Aspiration of Thyroid Nodules in a Series of 1,100 Patients: Correlation Between Cytology and Histopathology Original Article.

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