2022
DOI: 10.1002/hsr2.798
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Repositioning potentials of smallpox vaccines and antiviral agents in monkeypox outbreak: A rapid review on comparative benefits and risks

Abstract: Background and aims: There is a sought for vaccines and antiviral agents as countermeasures for the recent monkeypox outbreak. Here, we aimed to review and discuss the repurposing potentials of smallpox vaccines and drugs in monkeypox outbreaks based on their comparative benefits and risks. Therefore, we conducted this rapid review and discussed the repurposing potentials of smallpox vaccines and drugs in monkeypox infection.Methods: Here, we searched Google Scholar and PubMed for relevant information and data… Show more

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Cited by 50 publications
(69 citation statements)
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“…Recent research indicates that smallpox vaccines are 85% effective in preventing monkeypox infection [8].…”
Section: Discussionmentioning
confidence: 99%
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“…Recent research indicates that smallpox vaccines are 85% effective in preventing monkeypox infection [8].…”
Section: Discussionmentioning
confidence: 99%
“…Patients report corneal scarring, conjunctivitis, vomiting, bronchopneumonia, sepsis, and encephalitis as additional complications [ 7 ]. Recent research indicates that smallpox vaccines are 85% effective in preventing monkeypox infection [ 8 ].…”
Section: Discussionmentioning
confidence: 99%
“…It continues its spreading and has infected about 100 countries far away from Central and West Africa. 36 Also, it is now not confined among the travelers but rather spreading locally among the local communities. The chance for human-to-human spreading is alarming for family members along with providers caring for contaminated persons.…”
Section: Discussionmentioning
confidence: 99%
“…7 Unsurprisingly, there is DISCUSSION evidence of immunity against MPX among individuals previously immunized against smallpox. 8 Monkeypox is closely related to smallpox and the vaccines used for MPX are developmentally related to smallpox. Therefore, there may be a similar propensity to PR in vaccinated patients.…”
Section: Monkeypox Vaccinationmentioning
confidence: 99%