Repositioning Vitamin C as a Promising Option to Alleviate Complications associated with COVID-19

Farjana, Mithila; Moni, Akhi; Sohag, Abdullah Al Mamun; Hasan, Adeba; Hannan, Md. Abdul; Hossain, Md. Golzar; Uddin, Jamal

doi:10.3947/ic.2020.52.4.461

Cited by 26 publications

(19 citation statements)

References 109 publications

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“…Therefore, one important activity of vitamin C is to block oxidative stresses, therefore, reducing or preventing productions of reactive oxygen and nitrogen species derived from cellular activities in response to bacterial and viral infections. The viral infections may trigger cytokine storms and lead to increased oxidative stresses in cells and tissues [ 41 ].…”

Section: Vitamin C and Its Potential For The Protection Of Renal Injury In Patients With Covid-19mentioning

confidence: 99%

“…The antioxidant and anti-inflammatory effects of vitamin C may protect endothelial cells, and thus reduce the incidence of multiple organ failures [ 64 ]. In animal studies, the infection of H3N2 can kill mice that are deficient in vitamin C [ 41 ]. Here, vitamin C has been thought to be needed for anti-influenza virus responses in the early phase of infection, which involves the production of IFN-α/β.…”

Section: Vitamin C and Its Potential For The Protection Of Renal Injury In Patients With Covid-19mentioning

confidence: 99%

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The Potential Use of Vitamin C to Prevent Kidney Injury in Patients with COVID-19

Wen

et al. 2021

Diseases

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The newly found SARS-CoV-2 has led to the pandemic of COVID-19, which has caused respiratory distress syndrome and even death worldwide. This has become a global public health crisis. Unfortunately, elders and subjects with comorbidities have high mortality rates. One main feature of COVID-19 is the cytokine storm, which can cause damage in cells and tissues including the kidneys. Here, we reviewed the current literature on renal impairments in patients with COVID-19 and analyzed the possible etiology and mechanisms. In addition, we investigated the potential use of vitamin C for the prevention of renal injury in those patients. It appears that vitamin C could be helpful to improve the outcomes of patients with COVID-19. Lastly, we discussed the possible protective effects of vitamin C on renal functions in COVID-19 patients with existing kidney conditions.

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Section: Vitamin C and Its Potential For The Protection Of Renal Injury In Patients With Covid-19mentioning

confidence: 99%

Section: Vitamin C and Its Potential For The Protection Of Renal Injury In Patients With Covid-19mentioning

confidence: 99%

The Potential Use of Vitamin C to Prevent Kidney Injury in Patients with COVID-19

Wen

et al. 2021

Diseases

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“…An example of such alternative therapy is found in the application of vitamin D, which has been suggested to help reduce the effect of the pandemic on maternal and child health. 10 Other speculative suggestions include the idea that vitamin C could help with COVID-19-related symptoms, 11 or that honey may have a positive impact on COVID-19 recovery. 12 Pharmacological intervention using natural products is considered another example of alternative medicine.…”

Section: Alternative Therapiesmentioning

confidence: 99%

Thymoquinone: A Promising Natural Compound with Potential Benefits for COVID-19 Prevention and Cure

Badary¹,

Hamza²,

Tikamdas³

2021

DDDT

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“…El suplemento con vitamina C se ha utilizado en pacientes con COVID-19 desde 6 hasta 24 g/ día por vía intravenosa (IV) durante una semana, mostrando seguridad y varios grados de eficacia (74,75). Las dosis recomendadas de vitamina C para esta enfermedad respiratoria, oscila entre 1-3 g/día (76)(77)(78). Se pueden administrar con seguridad hasta 0.5 g/kg de peso, de ácido ascórbico al día, incluso a largo plazo (79).…”

Section: Las Vitaminas C Y D Como Suplementos O Coadyuvantes En El Tratamiento Del Covid-19unclassified

Importancia del metabolismo y consumo de las vitaminas D y C durante la infección por SARS-CoV-2

et al. 2021

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VITAMINAS D Y C SOBRE COVID 19Introducción. Desde diciembre de 2019 el mundo ha vivido una emergencia de salud pública debido a la aparición de un nuevo coronavirus, el SARS-CoV-2. Los estudios epidemiológicos sugieren que la capacidad del sistema inmunológico modificado por diversos factores de riesgo puede ser algo determinante en el pronóstico del paciente, así como se les ha atribuido un efecto importante como protectores a las vitaminas C y D.Objetivo. Esta revisión tiene como objetivo investigar los posibles mecanismos protectores de las vitaminas C y D como antioxidantes e inmunomodulares durante el curso de la enfermedad de COVID-19.Metodología. Se empleó una búsqueda sistemática en bases de datos como PUBMED para identificar estudios clínicos, así como estudios en modelos animales e in vitro que proponen los mecanismos por los cuales las vitaminas C y D pueden desempeñar un papel antiinflamatorio y antioxidante durante la infección con COVID-19.Palabras clave: Vitamina C, vitamina D, SARS-CoV-2, Inmunomodulación

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Repositioning Vitamin C as a Promising Option to Alleviate Complications associated with COVID-19

Cited by 26 publications

References 109 publications

The Potential Use of Vitamin C to Prevent Kidney Injury in Patients with COVID-19

The Potential Use of Vitamin C to Prevent Kidney Injury in Patients with COVID-19

Thymoquinone: A Promising Natural Compound with Potential Benefits for COVID-19 Prevention and Cure

Importancia del metabolismo y consumo de las vitaminas D y C durante la infección por SARS-CoV-2

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